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  4. CACNB4 Antibody

CACNB4 Antibody

  • 中文名稱：
    CACNB4兔多克隆抗體
  • 貨號：
    CSB-PA004414LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA004414LA01HU at dilution of 1:100
    • Immunofluorescent analysis of PC-3 cells using CSB-PA004414LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CACNB4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CAB4 antibody; CACB4_HUMAN antibody; Cacnb4 antibody; CACNLB4 antibody; Calcium channel voltage dependent beta 4 subunit antibody; Calcium channel voltage dependent subunit beta 4 antibody; Calcium channel voltage-dependent subunit beta 4 antibody; Dihydropyridine sensitive L type calcium channel beta 4 subunit antibody; EA5 antibody; EIG9 antibody; EJM antibody; EJM4 antibody; EJM6 antibody; Voltage-dependent L-type calcium channel subunit beta-4 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Voltage-dependent L-type calcium channel subunit beta-4 protein (1-217AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，CACNB4 Antibody (CSB-PA004414LA01HU)，的標(biāo)記方式是Non-conjugated。對于CACNB4 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA004414LB01HU CACNB4 Antibody, HRP conjugated ELISA
    FITC CSB-PA004414LC01HU CACNB4 Antibody, FITC conjugated
    Biotin CSB-PA004414LD01HU CACNB4 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
  • 基因功能參考文獻(xiàn)：
    1. The nuclear targeting properties of the truncated beta(4b(1-481)) subunit in tsA-201 cells, skeletal myotubes, and in hippocampal neurons, were investigated. PMID: 24875574
    2. Genome-wide association studies identify CACNB4 mutation releated to juvenile myoclonic epilepsy. PMID: 23756480
    3. Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy PMID: 22892567
    4. The Ca2+ channel beta4c subunit interacts with heterochromatin protein 1 gama via a PXVXL binding motif. PMID: 21220418
    5. CACNB4 is associated with acute lung injury in mice PMID: 21297076
    6. The novel nucleotide substitution T87C (D29D)in CACNB4 was observed in 2 migrainous vertigo patients and was not present in control DNA samples. PMID: 16866717
    7. No pathogenic mutation were identified in CACNB4. PMID: 18446307
    8. plays a role in neurotransmitter release. PMID: 18712068

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  • 相關(guān)疾病：
    Epilepsy, idiopathic generalized 9 (EIG9); Juvenile myoclonic epilepsy 6 (EJM6); Episodic ataxia 5 (EA5)
  • 蛋白家族：
    Calcium channel beta subunit family
  • 組織特異性：
    Expressed predominantly in the cerebellum and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1404

    OMIM: 601949

    KEGG: hsa:785

    STRING: 9606.ENSP00000438949

    UniGene: Hs.120725