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  4. CCDC106 Antibody

CCDC106 Antibody

  • 中文名稱：
    CCDC106兔多克隆抗體
  • 貨號：
    CSB-PA961263
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from Jurkat cells using Coiled-coil domain-containing protein 106 antibody and the same antibody preincubated with blocking peptide.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CCDC106 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CCDC106
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Peptide sequence around aa.2~6 (N-D-R-S-S) derived from Human Coiled-coil domain-containing protein 106.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Promotes the degradation of p53/TP53 protein and inhibits its transactivity.
  • 基因功能參考文獻(xiàn)：
    1. Our studies revealed that CCDC106 is associated with non-small cell lung cancer progression and unfavorable prognosis. CCDC106 enhanced Cyclin A2 and Cyclin B1 expression and promoted A549 and H1299 cell proliferation, which depended on AKT signaling. These results suggest that CCDC106 may be a novel target for lung cancer treatment. PMID: 28460455
    2. CCDC106 promotes the degradation of p53 protein and inhibits its transactivity. PMID: 20159018
  • 亞細(xì)胞定位：
    Nucleus. Note=Colocalizes with p53/TP53.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30181

    OMIM: 613478

    KEGG: hsa:29903

    UniGene: Hs.82482