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CDON Antibody

  • 中文名稱：
    CDON兔多克隆抗體
  • 貨號(hào)：
    CSB-PA242369
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Immunofluorescence analysis of MCF-7 cells, using CDON antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CDON Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human CDON.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:100-1:500
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.
  • 基因功能參考文獻(xiàn)：
    1. We identified a novel heterozygous nonsense CDON mutation in a case of Pituitary Stalk Interruption Syndrome who presented with neonatal hypoglycemia and cholestasis PMID: 26529631
    2. CDO is required for proliferation and survival of lung cancer cells via Hh signaling. PMID: 25369201
    3. These data support the view that cell-adhesion molecule-related/downregulated by oncogenes (CDON) acts as a tumor suppressor in neuroblastomas, and that CDON is tightly regulated by miRNAs. PMID: 25313246
    4. Single-nucleotide polymorphism in CDON is associated with biochemical recurrence in prostate cancer. PMID: 24740842
    5. Mutations in the CDON cause holoprosencephaly. (Review) PMID: 22326621
    6. We found that CDON is overexpressed in prostate cancer PMID: 21849809
    7. CDON must associate with both ligand and other hedgehog-receptor components, particularly PTCH1, for signaling to occur and disruption of the latter interactions is a mechanism of holoprosencephaly. PMID: 21802063
    8. Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner PMID: 20519495
    9. CDO and BOC play a role in differentiation of cells in the skeletal muscle lineage PMID: 12720294
    10. CDO and BOC forms complexes with specific cadherins that mediate some of the promyogenic effects of cell-cell contact. PMID: 12634428
    11. Targeted inactivation of Cdon in the mouse results in mild holoprosencephaly, suggesting a link to signaling pathways that control midline development such as the Sonic hedgehog pathway. PMID: 12620190

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  • 相關(guān)疾病：
    Holoprosencephaly 11 (HPE11)
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass membrane protein.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 17104

    OMIM: 608707

    KEGG: hsa:50937

    STRING: 9606.ENSP00000263577

    UniGene: Hs.38034