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CELF4 Antibody

  • 中文名稱：
    CELF4兔多克隆抗體
  • 貨號：
    CSB-PA883643LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA883643LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CELF4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CELF4
  • 別名：
    CELF4 antibody; BRUNOL4 antibody; CUGBP Elav-like family member 4 antibody; CELF-4 antibody; Bruno-like protein 4 antibody; CUG-BP- and ETR-3-like factor 4 antibody; RNA-binding protein BRUNOL-4 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CUGBP Elav-like family member 4 protein (120-236AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，CELF4 Antibody (CSB-PA883643LA01HU)，的標(biāo)記方式是Non-conjugated。對于CELF4 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA883643LB01HU CELF4 Antibody, HRP conjugated ELISA
    FITC CSB-PA883643LC01HU CELF4 Antibody, FITC conjugated
    Biotin CSB-PA883643LD01HU CELF4 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.
  • 基因功能參考文獻(xiàn)：
    1. The present study refines the molecular and neuropsychiatric phenotype associated with 18q12.2 deletion leading to CELF4 haploinsufficiency and provides evidence for a role for CELF4 in brain development and autism spectrum disorders. PMID: 28407444
    2. Authors report a modifying effect of a polymorphism of CELF4 on the dose-dependent association between anthracyclines and cardiomyopathy, which possibly occurs through a pathway that involves the expression of abnormally spliced TNNT2 variants. PMID: 26811534
    3. Determination of CELF4 protein domains required for RNA splicing. PMID: 14973222
    4. validated occurrence of an unusual TG 3' splice site in intron 6 PMID: 17672918
  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    CELF/BRUNOL family
  • 組織特異性：
    Ubiquitous. Strongly expressed in the cerebellum, hippocampus, amygdala, temporal and frontal cortex and frontal lobes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14015

    OMIM: 612679

    KEGG: hsa:56853

    STRING: 9606.ENSP00000355089

    UniGene: Hs.435976