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CEP120 Antibody

  • 中文名稱：
    CEP120兔多克隆抗體
  • 貨號(hào)：
    CSB-PA836696ESR2HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA836696ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA836696ESR2HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CEP120 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CEP120
  • 別名：
    CCDC100 antibody; CE120_HUMAN antibody; Centrosomal protein of 120 kDa antibody; Cep120 antibody; Coiled-coil domain-containing protein 100 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Centrosomal protein of 120 kDa protein (1-270AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner.
  • 基因功能參考文獻(xiàn)：
    1. The CEP120-associated phenotype ranges from mild classical JS in four patients to more severe conditions in two fetuses. PMID: 27208211
    2. We establish a novel locus for Jeune asphyxiating thoracic dystrophy on 5q23.2 by linkage analysis and demonstrate that a mutation in CEP120 within this locus is the most likely cause of the disease. PMID: 25361962
    3. Functional characterization of the homologous mouse gene, and comparison to the human protein. PMID: 17920017
  • 相關(guān)疾?。?/div>
    Short-rib thoracic dysplasia 13 with or without polydactyly (SRTD13); Joubert syndrome 31 (JBTS31)
  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    CEP120 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 26690

    OMIM: 613446

    KEGG: hsa:153241

    STRING: 9606.ENSP00000303058

    UniGene: Hs.483209