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  4. CEP250 Antibody

CEP250 Antibody

  • 中文名稱：
    CEP250兔多克隆抗體
  • 貨號：
    CSB-PA005239GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CEP250 antibody; CEP2 antibody; CNAP1Centrosome-associated protein CEP250 antibody; 250 kDa centrosomal protein antibody; Cep250 antibody; Centrosomal Nek2-associated protein 1 antibody; C-Nap1 antibody; Centrosomal protein 2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human CEP250,C-NAP1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    May be involved in ciliogenesis. Probably plays an important role in centrosome cohesion during interphase.
  • 基因功能參考文獻(xiàn)：
    1. C-NAP1-null cells were viable and had an increased frequency of premature centriole separation, accompanied by reduced density of the centriolar satellites, with reexpression of C-NAP1 rescuing both phenotypes. Centrosome amplification induced by DNA damage or by PLK4 or CDK2 overexpression was markedly reduced in the absence of C-NAP1. PMID: 28100636
    2. ASPP1/2 interacted with centrosome linker protein C-Nap1. Co-depletion of ASPP1 and ASPP2 inhibited re-association of C-Nap1 with centrosome at the end of mitosis. PMID: 25660448
    3. multisite phosphorylation precipitates centrosome disjunction at the onset of mitosis PMID: 24695856
    4. A homozygous nonsense CEP250 mutation, in combination with a heterozygous C2orf71 nonsense mutation, causes an atypical form of Usher syndrome, characterised by early-onset sensorineural hearing loss and a relatively mild retinitis pigmentosa. PMID: 24780881
    5. Centlein complexes with C-Nap1 and Cep68 at the proximal ends of centrioles during interphase. PMID: 24554434
    6. C-NAP1 and rootletin restrain DNA damage-induced centriole splitting and facilitate ciliogenesis. PMID: 23070519
    7. Data show that the dissociation of C-Nap1 from mitotic centrosomes is regulated by localized phosphorylation rather than generalized proteolysis. PMID: 12140259
    8. CEP135 acts as a platform protein for C-NAP1 at the centriole. PMID: 18851962

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  • 亞細(xì)胞定位：
    Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Note=Component of the core centrosome. In interphase cells, it specifically associates with the proximal ends of both mother and daughter centrioles. Associates with the centrosome in interphase cells. In mitotic cells, it dissociates from the mitotic spindle poles. At the end of cell division, it reaccumulates at centrosomes.
  • 組織特異性：
    Ubiquitously and weakly expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1859

    OMIM: 609689

    KEGG: hsa:11190

    STRING: 9606.ENSP00000380661

    UniGene: Hs.443976