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  4. CES3 Antibody

CES3 Antibody

  • 中文名稱：
    CES3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA005260GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CES3
  • 別名：
    Carboxylesterase 3 antibody; CES 3 antibody; Ces3 antibody; ES3 antibody; EST3_HUMAN antibody; FLJ21736 antibody; Liver carboxylesterase 31 homolog antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Human CES3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.
  • 基因功能參考文獻(xiàn)：
    1. This study provides the first evidence of functional compensation whereby increased expression of CES3 restores intracellular cholesteryl ester hydrolytic activity and free cholesterol efflux in CES1-deficient cells. PMID: 22700792
    2. Studies indicate that CES3 mRNA isoform expression in several tissues, particularly in colon, trachea and in brain. PMID: 20422440
    3. CES3 seems to have a lower catalytic efficiency than the other two CESs for selected substrates. PMID: 19508181
    4. pharmacogenomic characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes PMID: 18794728
  • 亞細(xì)胞定位：
    Endoplasmic reticulum lumen.
  • 蛋白家族：
    Type-B carboxylesterase/lipase family
  • 組織特異性：
    Expressed in liver, colon and small intestine.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1865

    OMIM: 605279

    KEGG: hsa:23491

    STRING: 9606.ENSP00000304782

    UniGene: Hs.268700