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CHN1 Antibody

  • 中文名稱：
    CHN1兔多克隆抗體
  • 貨號：
    CSB-PA005368ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: CHN1 antibody at 6.08µg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: MCF-7 whole cell lysate
      Lane 3: Jurkat whole cell lysate
      Lane 4: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 54, 39, 51 kDa
      Observed band size: 51 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA005368ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CHN1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CHN1
  • 別名：
    A-chimaerin antibody; Alpha-chimerin antibody; ARHGAP2 antibody; CHIN_HUMAN antibody; CHN antibody; Chn1 antibody; N chimaerin antibody; N chimerin antibody; N-chimaerin antibody; N-chimerin antibody; NC antibody; Rho GTPase-activating protein 2 antibody; RHOGAP2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human N-chimaerin protein (1-200AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.
  • 基因功能參考文獻(xiàn)：
    1. CHN1 mutations were identified in 2 bilateral cases and in 1 parent of 1 affected case. One mutation is novel and occurred with additional vertical gaze abnormalities. PMID: 29031989
    2. CHN1 and TNFAIP3 are candidate biomarkers for esophageal squamous cell carcinomas PMID: 27072986
    3. These findings reveal a role for ephrin bidirectional signaling upstream of mutant alpha2-chimaerin in Duane retraction syndrome, which may contribute to the selective vulnerability of abducens motor neurons in this disorder PMID: 28346224
    4. this study shows that serum chemerin is an independent risk factor of prognosis of non-small cell lung cancer patients PMID: 28160556
    5. reduced alpha1-chimaerin expression in the brain of Alzheimer's disease cases, suggesting a role in the upregulation of Rac1 activity during the disease process. PMID: 25676811
    6. The patients most similar belong to families with a small or absent cranial nerve VI and septo-optic hypoplasia who carry CHN1 mutations PMID: 25331612
    7. Analysis of the current pedigree expands the phenotypic spectrum of hyperactivating CHN1 mutations to include vertical strabismus and supraduction deficits in the absence of Duane retraction syndrome. PMID: 21715346
    8. Members of families segregating Duane retraction syndrome (DRS) as an autosomal dominant trait should be screened for mutations in the CHN1 gene, enhancing genetic counseling and permitting earlier diagnosis. PMID: 21555619
    9. We found no evidence for a causative involvement of CHN1 mutations in congenital ocular motor anomalies different from autosomal dominant Duane's retraction syndrome PMID: 20535495
    10. study concludes that CHN1 mutations are not a major cause of Duane's retraction syndrome among individuals with sporadic disease PMID: 20034095
    11. These two pedigrees double the published pedigrees known to map to the DURS2 locus and can thus contribute toward the search for the DURS2 gene PMID: 17197532
    12. DRS (Duane retraction syndrome) linked to the DURS2 locus is associated with bilateral abnormalities of many orbital motor nerves, and structural abnormalities of all EOMs except those innervated by the inferior division of CN3. PMID: 17197533
    13. Identify chimaerins as candidates for the downmodulation of Rac1 in T-lymphocytes and, in addition, uncover a novel regulatory mechanism that mediates their activation in T-cells. PMID: 18249095
    14. studying families with a variant form of Duane's retraction syndrome (DURS2-DRS), causative heterozygous missense mutations in CHN1 were identified; these are gain-of-function mutations that increase alpha2-chimaerin RacGAP activity PMID: 18653847
    15. analysis of an autoinhibitory mechanism that restricts C1 domain-mediated activation of the Rac-GAP alpha2-chimaerin PMID: 18826946
    16. Considerable intrafamilial clinical variability was observed in this Duane syndrome pedigree that carried a alpha2-chimaerin mutation PMID: 19541263

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  • 相關(guān)疾?。?/div>
    Duane retraction syndrome 2 (DURS2)
  • 組織特異性：
    In neurons in brain regions that are involved in learning and memory processes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1943

    OMIM: 118423

    KEGG: hsa:1123

    STRING: 9606.ENSP00000386741

    UniGene: Hs.380138