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CHP2 Antibody

  • 中文名稱：
    CHP2兔多克隆抗體
  • 貨號：
    CSB-PA869859
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from Jurkat cells, K562 cells and HT-29 cells, using CHP2 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CHP2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CHP2
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from internal of HumanCHP2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.
  • 基因功能參考文獻：
    1. CHP2 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
    2. chp2 expression in leukemia primary cells and leukemia cell lines is significantly increased. PMID: 18718049
    3. These findings suggest that CHP serves as an obligatory subunit that is required both for supporting the basic activity and regulating the pH-sensing of NHE1 via interactions between distinct parts of these proteins. PMID: 16710297
    4. overexpression of the CHP2 gene affects the biological behavior of ovarian cancer cell line OVCAR3 and is one of key mechanisms for ovarian carcinoma progression PMID: 17708351
  • 亞細胞定位：
    Nucleus. Cytoplasm. Cell membrane.
  • 蛋白家族：
    Calcineurin regulatory subunit family, CHP subfamily
  • 組織特異性：
    Expressed in malignantly transformed cells but not detected in normal tissues.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24927

    KEGG: hsa:63928

    STRING: 9606.ENSP00000300113

    UniGene: Hs.178589