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CIAO2A Antibody, FITC conjugated

  • 中文名稱：
    CIAO2A兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA872502LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) FAM96A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    FAM96A
  • 別名：
    CIAO2A antibody; CIA2A antibody; FAM96A antibody; Cytosolic iron-sulfur assembly component 2A antibody; MIP18 family protein FAM96A antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Cytosolic iron-sulfur assembly component 2A protein (1-160AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2, connecting cytosolic iron-sulfur protein maturation with cellular iron regulation. May play a role in chromosome segregation through establishment of sister chromatid cohesion. May induce apoptosis in collaboration with APAF1.
  • 基因功能參考文獻：
    1. our data suggest that hTERTR-FAM96A may serve as an efficient anti-tumor agent for the treatment of hepatocellular carcinoma. PMID: 28443470
    2. FAM96A expression was much reduced in tumorigenic ICC-SCs. PMID: 25716227
    3. CIA2B-CIA1-MMS19 and CIA2A-CIA1 assist different branches of Fe/S protein assembly and intimately link this process to cellular iron regulation via IRP1 Fe/S cluster maturation and IRP2 stabilization. PMID: 23891004
    4. putative metal-binding site of bacterial DUF59 proteins is not conserved in Fam96a, but Fam96a interacts tightly in vitro with Ciao1, the cytosolic iron-assembly protein PMID: 22683786
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    MIP18 family
  • 組織特異性：
    Substantially enriched in macrophages.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 26235

    KEGG: hsa:84191

    STRING: 9606.ENSP00000300030

    UniGene: Hs.439548