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CLDN14 Antibody

  • 中文名稱(chēng)：
    CLDN14兔多克隆抗體
  • 貨號(hào)：
    CSB-PA669859
  • 規(guī)格：
    ￥1100
  • 圖片：
    • Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane: Mouse pancreas tissue, Primary antibody: CSB-PA669859(CLDN14 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 50 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CLDN14
  • 別名：
    CLDN14; UNQ777/PRO1571; Claudin-14
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human CLDN14
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:10000
    WB 1:200-1:1000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
  • 基因功能參考文獻(xiàn)：
    1. This study suggested considerable genetic heterogeneity in the causation of hearing loss in Dhadkai. Recessive mutations were observed in at least three genes causing hearing loss: OTOF (p.R708X), SLC26A4 (p.Y556X) and CLDN14 (p.V85D). Mutation p.R708X appeared to be the major cause of hearing impairment in Dhadkai. PMID: 29434063
    2. CLDN14 might not be a major causative gene for NSHL in Chinese populations, which would contribute to fully understanding the genetic cause of NSHL in the East Asian populations PMID: 29447821
    3. Our data suggest that children with the INSM1 binding site within the CLDN14 risk haplotype have a higher likelihood of hypercalciuria and kidney stones. Enhanced CLDN14 expression may play a role in the pathophysiology of their hypercalciuria. PMID: 28229505
    4. All hearing impaired individuals, including the proband, are homozygous for a pathogenic variant of CLDN14, but this only explains the deafness. PMID: 27629923
    5. Extensive clinical recruitment and targeted screening suggest that CLDN14 p.(Ala163Val) represents a major founder variant for prelingual sensorineural hearing loss in the Newfoundland population. PMID: 27838790
    6. CLDN14 is a novel direct target of EZH2-mediated H3K27ME3 and plays role in EZH2-H3K27ME3-mediated hepatocellular carcinoma aggressiveness. PMID: 27207647
    7. The rs170183 was correlated with a decline in claudin 14 expression in both lymphoblastoid cell lines and T cells. PMID: 26842849
    8. Rs1801725 (Ala986-Ser), rs1042636 (Arg990Gly) of CaSR gene and rs219778, rs219780 (Thr229Thr) of CLDN14 gene were significantly associated with kidney stone disease in patients from the Eastern part of India. PMID: 26107257
    9. Claudin 14 expression was up-regulated in gastric cancer. PMID: 24325792
    10. Data suggest a possible role for Claudin14 in urinary calcium excretion. PMID: 23991001
    11. CLDN14 mutations can contribute to the aetiology of childhood/congenital deafness in Moroccan patients. PMID: 23590985
    12. Human Cldn-8 and -14 were shown to convey Clostridium perfringens enterotoxin-mediated cytotoxicity at pathophysiologically relevant concentrations of this toxin, although ~2-to-10-fold less efficiently than Cldn-4. PMID: 23322640
    13. OPRM1 genetic polymorphisms are associated with the plasma concentration of cotinine in a Taiwanese MMT cohort. Carriers with the major allele of SNP rs1799971 had a higher plasma cotinine concentration. PMID: 23235333
    14. The hearing loss due to novel CLDN14 mutations is prelingual, severe-to-profound with greater loss in the high frequencies. PMID: 22246673
    15. The CLDN14 promoter is activated by Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. PMID: 20494980
    16. Individuals with mutations of CLDN14 may have different degrees of hearing loss and the loss is greater at higher frequencies. PMID: 20811388
    17. The palmitoylation of claudin-14 is required for efficient localization into tight junctions but not stability or strand assembly. PMID: 15769849
    18. The ability of CLDN14 to be recruited to these junctions is crucial for the hearing process. PMID: 15880785
    19. Common, synonymous variants in the CLDN14 gene that associate with kidney stones, were discovered. PMID: 19561606

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  • 相關(guān)疾病：
    Deafness, autosomal recessive, 29 (DFNB29)
  • 亞細(xì)胞定位：
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Claudin family
  • 組織特異性：
    Liver, kidney. Also found in ear.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 2035

    OMIM: 605608

    KEGG: hsa:23562

    STRING: 9606.ENSP00000339292

    UniGene: Hs.660278