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CNPY2 Antibody

  • 中文名稱：
    CNPY2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA05034A0Rb
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: CNPY2 antibody at 2µg/ml + 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/15000 dilution
      Predicted band size: 21, 10 kDa
      Observed band size: 47 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA05034A0Rb at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CNPY2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CNPY2
  • 別名：
    Canopy 2 homolog (zebrafish) antibody; Cnpy2 antibody; CNPY2_HUMAN antibody; MIR-interacting saposin-like protein antibody; MSAP antibody; Protein canopy homolog 2 antibody; Putative secreted protein ZSIG9 antibody; TMEM4 antibody; Transmembrane protein 4 antibody; UNQ1943/PRO4426 antibody; ZSIG9 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Protein canopy homolog 2 protein (22-182AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，CNPY2 Antibody (CSB-PA05034A0Rb)，的標(biāo)記方式是Non-conjugated。對(duì)于CNPY2 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA05034B0Rb CNPY2 Antibody, HRP conjugated ELISA
    FITC CSB-PA05034C0Rb CNPY2 Antibody, FITC conjugated
    Biotin CSB-PA05034D0Rb CNPY2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.
  • 基因功能參考文獻(xiàn)：
    1. CNPY2 knockout resulted in the significant suppression of MHCC97H cell proliferation, tumor growth, and hemorrhage. PMID: 30415246
    2. Overexpression of CNPY2 can activate the AKT/GSK3beta pathway, which leads to the inactivation of GSK-3beta. The inactivation of GSK-3beta increases the level of Snail, and then decreases the expression of E-cadherin to promote EMT. PMID: 29569784
    3. CNPY2 can serve as a therapeutic target to promote the effect of chemotherapy in non-small cell lung cancer. PMID: 29864955
    4. CNPY2 isoform2 represents as a novel and valuable prognostic indicator for colorectal cancer patients. PMID: 29135454
    5. These findings suggested that CNPY2 promoted cancer cell growth in renal cell carcinoma cells through regulating TP53 gene expression. PMID: 28235487
    6. CNPY2 may play a critical role in colorectal cancer development by enhancing cell proliferation, migration, and angiogenesis and by inhibiting apoptosis through negative regulation of the p53 pathway PMID: 26835537
    7. CNPY2 is a HIF-1alpha-regulated, secreted angiogenic growth factor that promotes smooth muscle cell migration, proliferation, and tissue revascularization. PMID: 25589425
    8. Our results are consistent with an important role of FGF21 and Cnpy2/Msap in the regulation of LDLRs in cultured cells. PMID: 22378787
    9. MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain in fetal and adult brain. PMID: 12826659

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  • 亞細(xì)胞定位：
    Endoplasmic reticulum.
  • 蛋白家族：
    Canopy family
  • 組織特異性：
    Expressed in different tissues. Highest levels are detected in adult placenta, liver and pancreas.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13529

    OMIM: 605861

    KEGG: hsa:10330

    STRING: 9606.ENSP00000273308

    UniGene: Hs.8752