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COA6 Antibody

  • 中文名稱：
    COA6兔多克隆抗體
  • 貨號：
    CSB-PA683360LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA683360LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) COA6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    COA6
  • 別名：
    COA6 antibody; C1orf31Cytochrome c oxidase assembly factor 6 homolog antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Cytochrome c oxidase assembly factor 6 homolog protein (1-125AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，COA6 Antibody (CSB-PA683360LA01HU)，的標記方式是Non-conjugated。對于COA6 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA683360LB01HU COA6 Antibody, HRP conjugated ELISA
    FITC CSB-PA683360LC01HU COA6 Antibody, FITC conjugated
    Biotin CSB-PA683360LD01HU COA6 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV.
  • 基因功能參考文獻：
    1. Results find that COA6 associates with COX2 and is crucial for its maturation and complex IV biogenesis. Also, COA6 interacts with the copper chaperone SCO1 which indicates that COA6 is intrinsically involved in the copper delivery process for COX2. PMID: 26160915
    2. Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies. PMID: 25959673
    3. Co-purified with C7orf44 (the human ortholog of fungal COX assembly protein) PMID: 22356826
    4. COX assembly candidate, ortholog of fungal YMR244C-A PMID: 22356826
    5. Strong candidate gene for mitochondrial disease, based on recessive mutations detected in infantile patients PMID: 22277967
    6. Observational study of gene-disease association. (HuGE Navigator) PMID: 20877624

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  • 相關(guān)疾?。?/div>
    Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 4 (CEMCOX4)
  • 亞細胞定位：
    Mitochondrion intermembrane space.
  • 蛋白家族：
    Cytochrome c oxidase subunit 6B family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18025

    OMIM: 614772

    KEGG: hsa:388753

    STRING: 9606.ENSP00000355572

    UniGene: Hs.23198