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  4. COASY Antibody

COASY Antibody

  • 中文名稱：
    COASY兔多克隆抗體
  • 貨號：
    CSB-PA005699GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    COASY抗體（輔酶A合成酶）是一種酶，在輔酶A（CoA）的生物合成中催化最后一步反應(yīng)，CoA是參與多種代謝途徑的關(guān)鍵分子。COASY與多種疾病有關(guān)，包括神經(jīng)退行性疾病和癌癥。
    針對COASY的抗體是一種能夠特異性識別和結(jié)合COASY的蛋白質(zhì)。該抗體可用于多種研究應(yīng)用，如wb、免疫組化和免疫沉淀，以檢測細(xì)胞和組織中COASY的表達(dá)和定位。
    針對COASY的抗體可用于研究COASY在多種生物過程和疾病中的作用，如代謝和神經(jīng)退行性疾病。通過使用該抗體阻斷或調(diào)節(jié)COASY活性，研究人員可以探究COASY抑制的下游效應(yīng)，并可能開發(fā)針對COASY治療疾病的新療法。
  • Uniprot No.：
  • 基因名：
    COASY
  • 別名：
    Bifunctional coenzyme A synthase antibody; Bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase antibody; CoA synthase antibody; COASY antibody; COASY_HUMAN antibody; Coenzyme A synthase antibody; Dephospho-CoA kinase antibody; Dephospho-CoA pyrophosphorylase antibody; Dephosphocoenzyme A kinase antibody; DPCK antibody; DPCOAK antibody; NBP antibody; Nucleotide binding protein antibody; Pantetheine-phosphate adenylyltransferase antibody; Phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase antibody; pOV 2 antibody; POV-2 antibody; POV2 antibody; PPAT antibody; UKR1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human COASY
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.
  • 基因功能參考文獻(xiàn)：
    1. The recruitment of COASY inhibits CBP-mediated TPX2 acetylation, promoting TPX2 degradation for mitotic exit. PMID: 29531224
    2. The COASY protein contains a mitochondrial localization signal, a regulatory region and a domain for each of the two catalytic kinase domains: adenyl transferase and dephospho CoA PMID: 27021474
    3. DNA methylation levels in the COASY and SPINT1 promoter regions were considered to potentially be a convenient and useful biomarker for diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment. PMID: 27992572
    4. Exome sequencing revealed the presence of recessive missense mutations in COASY, encoding coenzyme A (CoA) synthase in neurodegeneration with brain iron accumulation PMID: 24360804
    5. EDC4 might contribute to regulation of CoA biosynthesis in addition to its scaffold function in processing bodies PMID: 22982864
    6. Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase). PMID: 11994049
    7. description of the existence of a novel CoA synthase isoform, which is the product of alternative splicing and possesses a 29aa extension at the N-terminus; termed it CoASy beta PMID: 16460672
    8. CoA synthase is involved in signaling events in the cell and forms a functional complex with p85alphaPI3K in vivo. PMID: 19482007

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  • 相關(guān)疾?。?/div>
    Neurodegeneration with brain iron accumulation 6 (NBIA6)
  • 亞細(xì)胞定位：
    Cytoplasm. Mitochondrion matrix.
  • 蛋白家族：
    Eukaryotic CoaD family
  • 組織特異性：
    Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liv
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29932

    OMIM: 609855

    KEGG: hsa:80347

    STRING: 9606.ENSP00000464814

    UniGene: Hs.296422