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COL12A1 Antibody

  • 中文名稱：
    COL12A1兔多克隆抗體
  • 貨號：
    CSB-PA994667
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue using Collagen XII α1 antibody.
    • Immunofluorescence analysis of COS-7 cells, using Collagen XII α1 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) COL12A1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    COL12A1
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human Collagen XII α1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC,IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.
  • 基因功能參考文獻(xiàn)：
    1. The study indicates that the spectrum of causative genes in extracellular matrix-related myopathies be extended to include COL12A1. PMID: 24334769
    2. collagen alpha-1 (XII) chain was expressed at dramatically higher (~10-fold) levels in breast PMID: 24262153
    3. Type XII collagen is overexpressed in permanent human and mouse corneal scars and could represent a new target to treat corneal scarring. PMID: 22969073
    4. In addition to binding collagen I, COMP binds to collagens XII and XIV via their C-terminal collagenous domains. PMID: 22573329
    5. COL12A1 is associated with anterior cruciate ligament ruptures among females PMID: 19443461
    6. this study identifies COL12A1 as the likely gene candidate within the recurrent 6q13 breakpoint and provides an alternative approach for detecting 6q13 anomalies in nondividing cells of chondromyxoid fibroma. PMID: 19648885
    7. induction of expression by sheare stress is associated with atherogenesis PMID: 12890494
    8. Results suggest that collagens XII and XIV might serve different functions during human embryonic development although their structures are highly similar. PMID: 15609093

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  • 相關(guān)疾?。?/div>
    Ullrich congenital muscular dystrophy 2 (UCMD2); Bethlem myopathy 2 (BTHLM2)
  • 亞細(xì)胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Fibril-associated collagens with interrupted helices (FACIT) family
  • 組織特異性：
    Found in collagen I-containing tissues: both isoform 1 and isoform 2 appear in amnion, chorion, skeletal muscle, small intestine, and in cell culture of dermal fibroblasts, keratinocytes and endothelial cells. Only isoform 2 is found in lung, placenta, ki
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2188

    OMIM: 120320

    KEGG: hsa:1303

    STRING: 9606.ENSP00000325146

    UniGene: Hs.101302