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  4. COPS7A Antibody

COPS7A Antibody

  • 中文名稱：
    COPS7A兔多克隆抗體
  • 貨號：
    CSB-PA880068ESR2HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA880068ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA880068ESR2HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA880068ESR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) COPS7A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    COPS7A
  • 別名：
    COP9 complex subunit 7a antibody; COP9 constitutive photomorphogenic homolog subunit 7A antibody; COP9 signalosome complex subunit 7a antibody; COP9 signalosome subunit 7A antibody; COPS7A antibody; CSN7A antibody; CSN7A_HUMAN antibody; Dermal papilla derived protein 10 antibody; Dermal papilla-derived protein 10 antibody; DERP10 antibody; JAB1 containing signalosome subunit 7a antibody; JAB1-containing signalosome subunit 7a antibody; SGN7a antibody; Signalosome subunit 7a antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human COP9 signalosome complex subunit 7a protein (1-275AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CSN7/EIF3M family, CSN7 subfamily
  • 組織特異性：
    Widely expressed. Expressed at high level in brain, heart and skeletal muscle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16758

    OMIM: 616009

    KEGG: hsa:50813

    STRING: 9606.ENSP00000229251

    UniGene: Hs.530823