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  4. COX10 Antibody

COX10 Antibody

  • 中文名稱：
    COX10兔多克隆抗體
  • 貨號：
    CSB-PA621520ESR2HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA621520ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA621520ESR2HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) COX10 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    2410004F01Rik antibody; AU042636 antibody; COX10 antibody; COX10_HUMAN antibody; Cytochrome c oxidase assembly protein antibody; Cytochrome c oxidase subunit X antibody; Heme A farnesyltransferase antibody; Heme O synthase antibody; OTTMUSP00000006085 antibody; Protoheme IX farnesyltransferase; mitochondrial antibody; Protoheme IX farnesyltransferase; mitochondrial precursor antibody; RP23-78H18.1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Protoheme IX farnesyltransferase, mitochondrial protein (1-160AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Converts protoheme IX and farnesyl diphosphate to heme O.
  • 基因功能參考文獻：
    1. On the basis of its pivotal role in regulating cell death upon COX dysfunction, CerS6 might potentially represent a novel target for therapeutic intervention in mitochondrial diseases caused by COX dysfunction. PMID: 25766330
    2. ISCU and COX10 are target genes of miR-210 related to mitochondrial metabolism PMID: 20498629
    3. COX 15 mRNA was significantly more abundant in the cerebral tissue of Alzheimer's disease (AD) patients and COX10 and COX15 SNP were significantly less represented in the patient group, suggesting a possible protective role toward the risk for AD PMID: 19826901
    4. The expression of the AOX, well-tolerated by the cells, compensates for both the growth defect and the pronounced oxidant-sensitivity of COX-deficient human cells. PMID: 20049701
    5. Cytochrome c oxidase is decreased significantly in platelets and hippocampus in Alzheimer patients compared to controls. PMID: 11959398
    6. COX10 has a role in mitochondrial heme A biosynthesis PMID: 12928484
    7. This study report a cytochrome c oxidase (COX)-deficient patient, clinically affected with Leigh-like disease, with a homozygous mutation in the COX10 start codon. PMID: 15455402
    8. Geranylgeranyltransferase inhibitor-2147 (GGTI-2147), an inhibitor of this enzyme prenylation, elicited significant inhibition of glucose-stimulated insulin secretion from INS 832/13 islet cells. PMID: 17192483

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  • 相關(guān)疾病：
    Mitochondrial complex IV deficiency (MT-C4D); Leigh syndrome (LS)
  • 亞細胞定位：
    Mitochondrion membrane; Multi-pass membrane protein.
  • 蛋白家族：
    UbiA prenyltransferase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2260

    OMIM: 220110

    KEGG: hsa:1352

    STRING: 9606.ENSP00000261643

    UniGene: Hs.462278