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COX17 Antibody

  • 中文名稱：
    COX17兔多克隆抗體
  • 貨號(hào)：
    CSB-PA619858LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: COX17 antibody at 3.5µg/ml + HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 7 kDa
      Observed band size: 7 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA619858LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA619858LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA619858LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) COX17 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    COX 17 antibody; COX17 antibody; COX17 cytochrome c oxidase assembly homolog (S. cerevisiae) antibody; COX17 cytochrome c oxidase assembly homolog antibody; COX17 homolog cytochrome c oxidase assembly protein antibody; COX17_HUMAN antibody; cytochrome c oxidase assembly protein cox17 homolog antibody; Cytochrome c oxidase copper chaperone antibody; Human homolog of yeast mitochondrial copper recruitment antibody; MGC104397 antibody; MGC117386 antibody; OTTHUMP00000215284 antibody; OTTHUMP00000215285 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Cytochrome c oxidase copper chaperone protein (1-63AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，COX17 Antibody (CSB-PA619858LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于COX17 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA619858LB01HU COX17 Antibody, HRP conjugated ELISA
    FITC CSB-PA619858LC01HU COX17 Antibody, FITC conjugated
    Biotin CSB-PA619858LD01HU COX17 Antibody, Biotin conjugated ELISA
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
  • 基因功能參考文獻(xiàn)：
    1. These results collectively indicate that Cox17 might not participate in the action of these anticancer organoruthenium complexes, and further verify the distinct anticancer mechanism of the organoruthenium(II) complexes from cisplatin. PMID: 27235272
    2. Data show that the redox state of cytochrome c oxidase assembly protein 17 (Cox17), mitochondrial membrane transport protein Mia40 and superoxide dismutase 1 (SOD1) in the cytoplasm were directly observed with in-cell NMR spectroscopy. PMID: 26589182
    3. Data suggest that Cox17 enhances the reactivity of some platinum/organoplatinum antineoplastic drugs but suppresses the reactivity of at least one platinum antineoplastic drug; glutathione modulates binding of platinum/organoplatinum drugs to Cox17. PMID: 26399480
    4. Functional role of two interhelical disulfide bonds in human Cox17 protein from a structural perspective. PMID: 21816817
    5. Data imply that up-regulation of COX17 function and increased cytochrome c oxidase activity are frequent features of lung carcinogenesis. PMID: 14612491
    6. The binding of copper to Cox17 is needed to activate cytochrome c oxidase by Cox17. PMID: 15504366
    7. Cox17-mediated copper metallation of Sco1, as well as the subsequent failure of Cu(A) site maturation, is the basis for the inefficient assembly of the cytochrome c oxidase complex in SCO1 patients PMID: 16520371
    8. Cox17 was studied with regard to its expression, purification, and formation of mixed disulfide adducts with sulfhydryl reagents. PMID: 17208454
    9. XAS (X-ray absorption spectroscopy) determined that Cu4Cox17 contains a Cu4S6-type copper-thiolate cluster, which may provide safe storage of an excess of copper ions PMID: 17672825
    10. Cu(I)HCox17(2S-S), i.e., the copper-loaded form of the protein, can transfer simultaneously copper(I) and two electrons to the human cochaperone Sco1 (HSco1) in the oxidized state, i.e., with its metal-binding cysteines forming a disulfide bond. PMID: 18458339
    11. the absence of Cox17 interferes with copper delivery to Cox2, but not to Cox1. PMID: 19393246

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  • 亞細(xì)胞定位：
    Mitochondrion intermembrane space. Cytoplasm.
  • 蛋白家族：
    COX17 family
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 2264

    OMIM: 604813

    KEGG: hsa:10063

    STRING: 9606.ENSP00000261070

    UniGene: Hs.534383