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  4. COX5B Antibody

COX5B Antibody

  • 中文名稱：
    COX5B兔多克隆抗體
  • 貨號：
    CSB-PA00404A0Rb
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: COX5B antibody at 2µg/ml + EC109 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/15000 dilution
      Predicted band size: 14 kDa
      Observed band size: 14, 65 kDa
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA00404A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) COX5B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    COX 5B antibody; COX5B antibody; COX5B_HUMAN antibody; COXVB antibody; Cytochrome c oxidase polypeptide Vb antibody; Cytochrome c oxidase polypeptide VB mitochondrial antibody; Cytochrome c oxidase subunit 5B antibody; Cytochrome c oxidase subunit 5B mitochondrial antibody; Cytochrome c oxidase subunit Vb antibody; mitochondrial antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Cytochrome c oxidase subunit 5B, mitochondrial protein (32-129AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，COX5B Antibody (CSB-PA00404A0Rb)，的標記方式是Non-conjugated。對于COX5B Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA00404B0Rb COX5B Antibody, HRP conjugated ELISA
    FITC CSB-PA00404C0Rb COX5B Antibody, FITC conjugated
    Biotin CSB-PA00404D0Rb COX5B Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
  • 基因功能參考文獻：
    1. Our results suggest that COX5B protein level might be associated with tumor size. COX5B overexpression indicated a worse DFS (p < 0.05) in breast cancer. PMID: 28592145
    2. These experiments suggest that the FAD group of cytochrome b5 reductase increase its solvent exposition upon complex formation promoting an efficient electron transfer between the proteins. PMID: 29111436
    3. silence of COX5B leads to metabolic disorders, such as increased glucose uptake and decreased lactate secretion PMID: 26506233
    4. Transfected the A549 cells with COX Vb small interfering or shRNA and observed a significant reduction of their COX activity, oxygen consumption, ATP and ability to grow in soft agar and as poorly differentiated tumors in athymic mice. PMID: 22917272
    5. Data show that Bcl-2 expression positively influences the targeting of nuclear-encoded COX Va and Vb to the mitochondria of cancer cells. PMID: 19834492

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  • 亞細胞定位：
    Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
  • 蛋白家族：
    Cytochrome c oxidase subunit 5B family
  • 數據庫鏈接：

    HGNC: 2269

    OMIM: 123866

    KEGG: hsa:1329

    STRING: 9606.ENSP00000258424

    UniGene: Hs.1342