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CPA6 Antibody

  • 中文名稱：
    CPA6兔多克隆抗體
  • 貨號(hào)：
    CSB-PA005880GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CPA6
  • 別名：
    CPA6 antibody; CPAHCarboxypeptidase A6 antibody; EC 3.4.17.- antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human CPA6
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II. Releases a C-terminal amino acid, with preference for large hydrophobic C-terminal amino acids and shows only very weak activity toward small amino acids and histidine.
  • 基因功能參考文獻(xiàn)：
    1. Common variants in PRPF31 and CPA6 were associated with worse and better metformin response, respectively. PMID: 29650774
    2. these mutations in CPA6 are deleterious and provide further evidence for the involvement of CPA6 mutations in the predisposition for several types of epilepsy. PMID: 25875328
    3. Significantly higher levels of DNA methylation are found in the CPA6 promoter in focal epilepsy and febrile seizure patients. PMID: 24290490
    4. These results provide further evidence for the involvement of CPA6 mutations in human epilepsy. PMID: 23105115
    5. CPA6 mutatins are genetically linked to an autosomal recessive familial form of febrile seizures and temporal lobe epilepsy (TLE), and are associated with sporadic TLE cases. PMID: 21922598
    6. Substrate specificity of human carboxypeptidase A6 PMID: 20855895
    7. The CPAH gene was interrupted in a patient with DURS carrying a translocation break point in the DURS1 region on chromosome 8q13. PMID: 12454025
    8. CPA6 may have a role in the regulation of neuropeptides in the extracellular environment within the olfactory bulb and other parts of the brain PMID: 18178555
    9. Thrombin activation of osteopontin (OPN) (resulting in OPN-R) and its subsequent inactivation by thrombin-activatable carboxypeptidase B (generating OPN-L) occurs locally within inflamed joints in rheumatoid arthritis. PMID: 19790060

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  • 相關(guān)疾病：
    Epilepsy, familial temporal lobe, 5 (ETL5); Febrile seizures, familial, 11 (FEB11)
  • 亞細(xì)胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Peptidase M14 family
  • 組織特異性：
    Expressed in the hippocampus, nucleus raphe, and cortex.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 17245

    OMIM: 609562

    KEGG: hsa:57094

    STRING: 9606.ENSP00000297770

    UniGene: Hs.658850