CPSF2 Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

Q9P2I0
基因名：

CPSF2
別名：

Cleavage and polyadenylation specific factor 2 antibody; cleavage and polyadenylation specific factor 2; 100kDa antibody; Cleavage and polyadenylation specificity factor 100 kDa subunit antibody; Cleavage and polyadenylation specificity factor subunit 2 antibody; CPSF 100 kDa subunit antibody; CPSF 2 antibody; CPSF100 antibody; Cpsf2 antibody; CPSF2_HUMAN antibody; KIAA1367 antibody; zgc:92484 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human CPSF2
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing.
基因功能參考文獻：
1. CPSF2 may have a role in Papillary Thyroid Carcinoma PMID: 26148673
2. CPSF2 and SYMPK, are RBFOX2 cofactors for both inclusion and exclusion of internal exons. PMID: 25921069
3. Decreased CPSF2 expression is associated with increased cellular invasion and cancer stem cell population, and more aggressive disease in papillary thyroid cancer. PMID: 24654752
4. Conserved residues in CPSF2 and CPSF-73 are required for assembly of the endonuclease activity that cleaves histone pre-mRNAs. PMID: 18688255
亞細(xì)胞定位：

Nucleus.
蛋白家族：

Metallo-beta-lactamase superfamily, RNA-metabolizing metallo-beta-lactamase-like family, CPSF2/YSH1 subfamily
數(shù)據(jù)庫鏈接：

HGNC: 2325

OMIM: 606028

KEGG: hsa:53981

STRING: 9606.ENSP00000298875

UniGene: Hs.657632