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CRYGS Antibody

  • 中文名稱：
    CRYGS兔多克隆抗體
  • 貨號(hào)：
    CSB-PA006025ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: CRYGS antibody at 6.87 μg/ml + Mouse eye tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 21 kDa
      Observed band size: 21, 23 kDa
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA006025ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA006025ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CRYGS Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CRYGS
  • 別名：
    AI327013 antibody; Beta-crystallin S antibody; CRBS_HUMAN antibody; CRYG8 antibody; crygs antibody; Crystallin; gamma 8 antibody; Crystallin; gamma polypeptide 8 antibody; Crystallin; gamma S antibody; CTRCT20 antibody; Gamma crystallin S antibody; Gamma S crystallin antibody; Gamma-crystallin S antibody; Gamma-S-crystallin antibody; Opacity due to poor secondary fiber cell junction; recessive nuclear cataract antibody; Opj antibody; rncat antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Beta-crystallin S protein (1-178AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Crystallins are the dominant structural components of the vertebrate eye lens.
  • 基因功能參考文獻(xiàn)：
    1. aberrant modifications in gammaS-crystallin structure might contribute to the lower stability and higher aggregatory potency of the mutated protein, which subsequently resulted in cataracts in the patients PMID: 29857103
    2. The Tyr67Asn substitution was predicted to decrease the local hydrophobicity and affect the three-dimensional structure of gammaS-crystallin, and resulted in a portion of mutant protein translocation from the cytoplasm to cell membrane. This observations expand the mutation spectrum of CRYGS and provide further evidence for the genetic basis and molecular mechanism of congenital cataract. PMID: 29964096
    3. Cataract-related G18V point mutation affects CRYGS stability and hydration. PMID: 27052457
    4. novel mutation (G57W) in CRYGS in this Chinese family is associated with autosomal dominant pulverulent cataract. PMID: 24328668
    5. The data suggest that enhanced attractive protein-protein interactions, arising from the deamidation of HGS, promote protein aggregation, thereby leading to increased light scattering and opacity over time. PMID: 26158710
    6. The effects of the V41M mutation on the structural changes of gamma S-crystallin were studied. PMID: 24287181
    7. The cataract-associated mutant D26G of human gammaS-crystallin is remarkably close to the wild type molecule in structural features, with only a microenvironmental change in the packing around the mutation site. PMID: 23761725
    8. replacement of valine in position 42 by the longer and bulkier methionine in human gammaS-crystallin perturbs the compact beta-sheet core packing topology in the N-terminal domain of the molecule PMID: 23284690
    9. age-dependent cleavage of gammaS-crystallin generates a peptide that binds to cell membranes PMID: 22995907
    10. The degree of deamidation for Gln92 and Gln170 was found to increase from birth to teen-age years and then to remain constant for four decades. PMID: 22593035
    11. Molecular dynamics (MD) simulations, circular dichroism (CD), and dynamic light scattering (DLS) measurements were used to investigate the aggregation propensity of the eye-lens protein gammaS-crystallin. PMID: 21244846
    12. Partially folded aggregation intermediates of human gammaD-, gammaC-, and gammaS-crystallin are recognized and bound by human alphaB-crystallin. PMID: 20621668
    13. Deamidation in cataractous lenses is influenced by surface exposure. PMID: 12093281
    14. A lens gamma S-crystallin has been identified with an in vivo modification, S-methylation of cysteine residues, that may block intermolecular disulfide bondng and serve as a form of protection against cataract. PMID: 12475213
    15. when glutathione becomes bound to gammaS-crystallin, it causes it to bind in turn to the beta-crystallin polypeptides to form a dimer PMID: 14763903
    16. report a novel missense mutation, p.V42M, in CRYGS associated with bilateral congenital cataract in a family of Indian origin PMID: 19262743
    17. Fast charge transfer quenching is an evolved property of the gamma S-crystallin fold, probably protecting it from ultraviolet-induced photodamage. PMID: 19358562
    18. Results confirm the high stability of wild-type HgammaS-crystallin and demonstrates that the G18V mutation destabilizes the protein toward heat and GuHCl-induced unfolding. PMID: 19558189

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  • 相關(guān)疾?。?/div>
    Cataract 20, multiple types (CTRCT20)
  • 蛋白家族：
    Beta/gamma-crystallin family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2417

    OMIM: 116100

    KEGG: hsa:1427

    STRING: 9606.ENSP00000312099

    UniGene: Hs.376209