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CTNNA2 Antibody

  • 中文名稱：
    CTNNA2兔多克隆抗體
  • 貨號：
    CSB-PA006165GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Alpha catenin related protein antibody; Alpha N catenin antibody; Alpha N-catenin antibody; Alpha-catenin-related protein antibody; Cadherin associated protein related antibody; Cancer/testis antigen 114 antibody; CAP R antibody; CAPR antibody; Catenin (cadherin associated protein) alpha 2 antibody; Catenin alpha 2 antibody; Catenin alpha-2 antibody; CT114 antibody; CTNA2_HUMAN antibody; CTNN A2 antibody; CTNNA 2 antibody; CTNNA2 antibody; CTNR antibody; DKFZp686H02198 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human CTNNA2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.
  • 基因功能參考文獻(xiàn)：
    1. Single nucleotide polymorphisms in CTNNA2 show associations in Schizophrenia and general cognitive function. PMID: 28746715
    2. One association in the CTNNA2 gene on chromosome 2p12 [rs1567532, hazard ratio (HR) = 1.75, 95% confidence interval (CI) 1.19-2.58, P = 0.005 for homozygotes for the minor allele] and one in the last intron of the RUNX2 gene on chromosome 6p21 (rs12209785, HR = 0.88, 95% CI 0.80-0.98, P = 0.014 for heterozygotes) are of particular relevance. These loci do not coincide with those that showed the strongest associations in t PMID: 27497070
    3. SNP 50-kb upstream from CTNNA2 was associated with impulsivity in Native American sample. PMID: 27167163
    4. Single nucleotide polymorphism in CTNNA2 is associated with breast cancer susceptibility. PMID: 25824743
    5. CTNNA2 gene increases the risk of alcohol addiction in White women. PMID: 25041903
    6. CTNNA2 and CTNNA3 are tumor suppressor genes frequently mutated in laryngeal carcinomas. PMID: 24100690
    7. Common variants in CTNNA2 are associated with excitement-seeking and risk-taking. PMID: 22833195
    8. CTNNA2 is differentially regulated by smoking in schizophrenic patients. PMID: 18163523
    9. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18519826

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  • 亞細(xì)胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell projection, axon. Nucleus.
  • 蛋白家族：
    Vinculin/alpha-catenin family
  • 組織特異性：
    Expressed in neural tissues, with strongest expression in fetal and adult brain. Expressed in the developing cortical plate and marginal zone of 20-week-old human fetal brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2510

    OMIM: 114025

    KEGG: hsa:1496

    UniGene: Hs.167368