CYTH3 Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

O43739
基因名：

CYTH3
別名：

CYTH3 antibody; ARF nucleotide-binding site opener 3 antibody; ARNO3 antibody; ARNO3 protein antibody; CYH3_HUMAN antibody; Cyth3 antibody; Cytohesin-3 antibody; General receptor of phosphoinositides 1 antibody; Grp1 antibody; PH antibody; PH, SEC7 and coiled-coil domain-containing protein 3 antibody; Protein ARNO3 antibody; PSCD3 antibody; SEC7 and coiled-coil domain-containing protein 3 antibody; SEC7 homolog C antibody; Sec7-3 antibody; Sec7c antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human CYTH3
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization.
基因功能參考文獻(xiàn)：
1. Cytohesin-3 was upregulated in hepatocellular carcinoma tissues, correlating with overall survival/relapse-free survival and tumor size/vascular invasion. PMID: 24966920
2. The PH domains of cytohesin 2/ARNO and cytohesin 3/GRP1 are responsible for the differential effects of these proteins on cell adhesion to fibronectin. PMID: 22454518
3. incorporation of the E345K charge reversal mutation into the GRP1 PH domain enhances PI(4,5)P(2) affinity 8-fold and yields constitutive plasma membrane targeting in cells PMID: 21932773
4. GRP1 is a new corepressor for thyroid hormone receptors, which modulates both positive and negative regulation by T3 by decreasing TR-complex formation on thyroid response elements PMID: 15878955
亞細(xì)胞定位：

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cell junction, tight junction.
組織特異性：

Almost absent from liver, thymus and peripheral blood lymphocytes.
數(shù)據(jù)庫鏈接：

HGNC: 9504

OMIM: 605081

KEGG: hsa:9265

STRING: 9606.ENSP00000297044

UniGene: Hs.487479