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Cleaved-C1S (R437) Antibody

  • 中文名稱：
    Cleaved-C1S (R437)兔多克隆抗體
  • 貨號(hào)：
    CSB-PA000017
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HeLa cells using Cleaved-C1s HC (R437) Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Basic proline rich peptide IB 1 antibody; C1 esterase antibody; C1S antibody; C1S_HUMAN antibody; Complement C1s subcomponent antibody; Complement C1s subcomponent heavy chain antibody; Complement C1s subcomponent light chain antibody; Complement component 1 s subcomponent antibody; Complement component 1 subcomponent s antibody; FLJ44757 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human C1s HC.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
  • 基因功能參考文獻(xiàn)：
    1. TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins. PMID: 24695853
    2. Data indicate that complement C1s mRNA level was low in ICR-derived glomerulonephritis (ICGN) mice liver as compared with age-matched ICR mice. PMID: 23989031
    3. A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4. PMID: 23592783
    4. Four positively charged amino acids on the serine protease domain appear to form a catalytic exosite that is required for efficient cleavage of C4 in the classical pathway of complement. PMID: 22855709
    5. Detailed mapping of post-translational modifications and insights into the C1r/C1s binding sites. PMID: 20008834
    6. Interaction with the prime side residues at the cleavage point in C1s enhances the affinity of the enzyme for complement 2 and complement 4 substrates; these prime subsite residues mediate positive cooperativity in the cleavage of the substrate. PMID: 14674770
    7. full specificity of the enzyme using a randomized phage display library PMID: 16169853
    8. There are splice variants of C1s mRNA transcripts in normal human cells PMID: 18062908

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  • 相關(guān)疾?。?/div>
    Complement component C1s deficiency (C1SD); Ehlers-Danlos syndrome, periodontal type, 2 (EDSPD2)
  • 蛋白家族：
    Peptidase S1 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 1247

    OMIM: 120580

    KEGG: hsa:716

    STRING: 9606.ENSP00000328173

    UniGene: Hs.458355