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Ctcfl Antibody

  • 中文名稱：
    Ctcfl兔多克隆抗體
  • 貨號(hào)：
    CSB-PA006139LA01MO
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: Ctcfl antibody at 6µg/ml + Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 74, 75 kDa
      Observed band size: 74 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Mus musculus (Mouse) Ctcfl Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    Ctcfl
  • 別名：
    Ctcfl antibody; Boris antibody; Transcriptional repressor CTCFL antibody; Brother of the regulator of imprinted sites antibody; CCCTC-binding factor antibody; CTCF paralog antibody; CTCF-like protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Mouse, Human
  • 免疫原：
    Recombinant Mouse Transcriptional repressor CTCFL protein (1-636AA)
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，Ctcfl Antibody (CSB-PA006139LA01MO)，的標(biāo)記方式是Non-conjugated。對(duì)于Ctcfl Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA006139LB01MO Ctcfl Antibody, HRP conjugated ELISA
    FITC CSB-PA006139LC01MO Ctcfl Antibody, FITC conjugated
    Biotin CSB-PA006139LD01MO Ctcfl Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
  • 基因功能參考文獻(xiàn)：
    1. CTCF and BORIS cooperate with additional Testis-specific transcriptional regulators to regulate gene expression in developing male gametes. PMID: 28145452
    2. The TGFB pathway as most affected by embryonic Ctcfl expression. PMID: 26169830
    3. down-regulation of endogenous BORIS by specific shRNAs inhibited both RNA transcription and cell cycle progression. The results altogether suggest a role for BORIS in coordinating S phase events with mitosis. PMID: 22724006
    4. Rb2 coimmunolocalizes with the chromatin insulator CCCTC-binding factor (CTCF) and BORIS in T-antigen-positive but not in T-antigen-negative cells. PMID: 22544282
    5. These findings show that BORIS expression is more widespread than previously believed, and suggest a role for BORIS in nucleolar function. PMID: 21811597
    6. These findings define transcriptional regulation of CST (Gal3st1) expression as a critical role for BORIS in spermatogenesis. PMID: 20231363
    7. CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region PMID: 18632606
    8. DNA damage-induced and ATR/Rfx1-mediated increase of miR-709 expression in exposed testes may be a protective mechanism that effectively decreases a cellular level of BORIS to prevent massive aberrant erasure of DNA methylation after radiation exposure. PMID: 19029807

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  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CTCF zinc-finger protein family
  • 組織特異性：
    Testis-specific.
  • 數(shù)據(jù)庫鏈接：