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DCUN1D5 Antibody

  • 中文名稱：
    DCUN1D5兔多克隆抗體
  • 貨號：
    CSB-PA006575GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    DCUN1D5
  • 別名：
    DCUN1D5DCN1-like protein 5 antibody; DCUN1 domain-containing protein 5 antibody; Defective in cullin neddylation protein 1-like protein 5 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human DCUN1D5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth.
  • 基因功能參考文獻：
    1. evidence that DCNL5 may be involved in innate immunity, as it is a direct substrate of the kinase IKKalpha during immune signalling. PMID: 29958295
    2. SCCRO5 has oncogenic potential that requires its function as a component of the neddylation E3. Neddylation activity and nuclear localization of SCCRO5 are important for its in vivo function. PMID: 24192928
    3. Overexpression of DCUN1D5 is associated with laryngeal squamous cell carcinoma. PMID: 23098533
  • 亞細胞定位：
    Nucleus. Cytoplasm, cytoskeleton, spindle.
  • 組織特異性：
    Weakly expressed in testis, skin and immune tissues (thymus, spleen and lymph nodes).
  • 數據庫鏈接：

    HGNC: 28409

    OMIM: 616522

    KEGG: hsa:84259

    STRING: 9606.ENSP00000260247

    UniGene: Hs.503716