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DDI2 Antibody

  • 中文名稱：
    DDI2兔多克隆抗體
  • 貨號：
    CSB-PA732937LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: DDI2 antibody at 4µg/ml
      Lane 1: A431 whole cell lysate
      Lane 2: HL60 whole cell lysate
      Lane 3: K562 whole cell lysate
      Lane 4: Caco-2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 45, 24, 47 kDa
      Observed band size: 47 kDa
    • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA732937LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DDI2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DDI2
  • 別名：
    DDI1 DNA damage inducible 1 homolog 2 antibody; Ddi2 antibody; DDI2_HUMAN antibody; DNA damage inducible 1 homolog 2 (S. cerevisiae) antibody; DNA damage inducible 1 homolog 2 antibody; DNA damage inducible protein 2 antibody; MGC14844 antibody; Protein DDI1 homolog 2 antibody; RP4-680D5.5 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Protein DDI1 homolog 2 protein (1-211AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，DDI2 Antibody (CSB-PA732937LA01HU)，的標記方式是Non-conjugated。對于DDI2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA732937LB01HU DDI2 Antibody, HRP conjugated ELISA
    FITC CSB-PA732937LC01HU DDI2 Antibody, FITC conjugated
    Biotin CSB-PA732937LD01HU DDI2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane. Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1. Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity.
  • 基因功能參考文獻：
    1. the 3D structures of the human Ddi2 UBL and RVP domains were solved and identified a new helical domain that extends on either side of the Rretroviral protease-like dimer. PMID: 27461074
    2. Here the authors show that the aspartyl protease DNA-damage inducible 1 homolog 2 (DDI2) is required to cleave and activate Nrf1. PMID: 27528193
  • 亞細胞定位：
    Cytoplasm, cytosol. Chromosome.
  • 蛋白家族：
    DDI1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24578

    KEGG: hsa:84301

    STRING: 9606.ENSP00000417748

    UniGene: Hs.718857