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  4. DDIAS Antibody
  • 中文名稱：
    DDIAS兔多克隆抗體
  • 貨號：
    CSB-PA006130
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 823 293T AD293 Hela HepG2 cells using NOXIN Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    DDIAS
  • 別名：
    Chromosome 11 open reading frame 82 antibody; DNA damage induced apoptosis suppressor antibody; DNA damage induced apoptosis suppressor protein antibody; FLJ13936 antibody; FLJ25416 antibody; FLJ38838 antibody; Nitric oxide inducible gene protein antibody; Nitric oxide-inducible gene protein antibody; Noxin antibody; NOXIN_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human NOXIN.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    May be an anti-apoptotic protein involved in DNA repair or cell survival.
  • 基因功能參考文獻(xiàn)：
    1. these findings indicate that the stability of the DDIAS protein is regulated by CHIP/HSP70-mediated proteasomal degradation and that CHIP overexpression stimulates the apoptosis of lung cancer cells in response to DNA-damaging agents PMID: 28079882
    2. Noxin facilitated the expression of Cyclin D1 and Cyclin E1 through activating P38-activating transcription factor 2 signaling pathway, thus enhanced cell growth of breast cancer PMID: 28618963
    3. EGF activates the ERK5/MEF2 pathway, which in turn induces DDIAS expression to promote cancer cell invasion by activating beta-catenin target genes PMID: 27412911
    4. DDIAS is a target of NFATc1 and is associated with cisplatin resistance in lung cancer cells. PMID: 26493727
    5. NOXIN overexpression, as a result of genomic DNA gain or amplification, promotes HCC tumorigenesis by accelerating DNA synthesis and cell cycle progression, where NOXIN functions as a cofactor of DNA polymerase-primase complex PMID: 25612832

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  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus.
  • 組織特異性：
    Highly expressed in colorectal and lung cancer tissues.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 26351

    KEGG: hsa:220042

    STRING: 9606.ENSP00000414687

    UniGene: Hs.165607