DDX23 Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

Q9BUQ8
基因名：

DDX23
別名：

100 kDa U5 snRNP-specific protein antibody; DDX23 antibody; DDX23_HUMAN antibody; DEAD box protein 23 antibody; EC 3.6.1.- antibody; Probable ATP-dependent RNA helicase DDX23 antibody; PRP28 homolog antibody; U5-100kD antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human DDX23
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA.
基因功能參考文獻(xiàn)：
1. These data provide new insights into the function of Prp28 in higher eukaryotes, and the requirements for stable tri-small nuclear ribonucleoproteins binding during B complex formation. PMID: 27377154
2. new basis of DDX23-Linc00630-HDAC1 signal axis for understanding its pathogenicity, which could be further developed as a valuable therapeutic strategy PMID: 28473661
3. pausing of RNA polymerase II (RNA Pol II) initiates a signaling cascade whereby the serine/arginine protein kinase 2 (SRPK2) phosphorylates the DDX23 helicase, culminating in the suppression of R-loops. PMID: 28076779
4. SRPK2 knock down results in hypophosphorylation of the arginine-serine (RS) domain-containing human PRP28 protein (PRP28, also known as DDX23), and destabilizes PRP28 association with the tri-snRNP. PMID: 18425142
亞細(xì)胞定位：

Nucleus. Chromosome.
蛋白家族：

DEAD box helicase family, DDX23/PRP28 subfamily
數(shù)據(jù)庫鏈接：

HGNC: 17347

OMIM: 612172

KEGG: hsa:9416

STRING: 9606.ENSP00000310723

UniGene: Hs.130098