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DGKK Antibody

  • 中文名稱：
    DGKK兔多克隆抗體
  • 貨號(hào)：
    CSB-PA099899
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using DGKK antibody.
    • Immunofluorescence analysis of COS-7 cells, using DGKK antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DGKK Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from C-terminal of Human DGKK.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC,IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable).
  • 基因功能參考文獻(xiàn)：
    1. FMRP is mostly associated diacylglycerol kinase kappa (Dgkkappa), a master regulator that controls the switch between diacylglycerol and phosphatidic acid signaling pathways. PMID: 27233938
    2. Dgkk appears to be a marker or mediator of squamous cell differentiation in development of mouse external genitalia. No association exists between Dgkk expression and formation of preputial cleft in the genital tubercle of diethylsilbestrol treated mice. PMID: 26162297
    3. Studied the relationship between DGKK single nucleotide polymorphisms (SNPs) and hypospadias risk in the Han Chinese population. PMID: 25327554
    4. Common variants in DGKK are strongly associated with risk of hypospadias PMID: 21113153
    5. DGK kappa is a novel human type II diacylglycerol kinase PMID: 16210324

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  • 亞細(xì)胞定位：
    Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    Eukaryotic diacylglycerol kinase family
  • 組織特異性：
    Expressed in testis, and to a lesser extent in placenta.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 32395

    OMIM: 300837

    KEGG: hsa:139189

    UniGene: Hs.38132