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DHX15 Antibody

  • 中文名稱：
    DHX15兔多克隆抗體
  • 貨號：
    CSB-PA006870LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: 293 whole cell lysate
      All lanes: DHX15 antibody at 3.7µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 91 kDa
      Observed band size: 91 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DHX15 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DHX15
  • 別名：
    ATP dependent RNA helicase #46 antibody; ATP-dependent RNA helicase #46 antibody; DBP1 antibody; DDX15 antibody; DEADH box 15 antibody; DEAH (Asp Glu Ala His) box polypeptide 15 antibody; DEAH box polypeptide 15 antibody; DEAH box protein 15 antibody; DHX15 antibody; DHX15_HUMAN antibody; HRH2 antibody; Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 antibody; PRP43 antibody; PrPp43p antibody; RNA helicase 2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 protein (371-502AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，DHX15 Antibody (CSB-PA006870LA01HU)，的標(biāo)記方式是Non-conjugated。對于DHX15 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA006870LB01HU DHX15 Antibody, HRP conjugated ELISA
    FITC CSB-PA006870LC01HU DHX15 Antibody, FITC conjugated
    Biotin CSB-PA006870LD01HU DHX15 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns.
  • 基因功能參考文獻(xiàn)：
    1. DHX15 regulates androgen receptor (AR) activity by modulating E3 ligase Siah2-mediated AR ubiquitination independent of its ATPase activity promoting prostate cancer progression. PMID: 28991234
    2. The crystal structure of human DHX15 reveals a domain organization of the mammalian DEAH/RHA family. PMID: 28580923
    3. Loss of DHX15 expression is associated with glioma. PMID: 28829764
    4. depletion of NKRF, XRN2 or DHX15 impairs an early pre-rRNA cleavage step. PMID: 28115624
    5. Mutation in DHX15 is associated with core-binding factor acute myeloid leukemia. PMID: 27798625
    6. Data indicate that DEAH-box RNA helicase DHX15/PRP43 stimulates the NF-kappaB and MAPK pathways downstream of virus-induced signaling adapter protein MAVS and contributes to MAVS-mediated cytokine production and apoptosis. PMID: 24782566
    7. The results suggest that activation of Prp43p by Gno1p/PINX1 within early pre-ribosomal particles is crucial for their subsequent maturation. PMID: 24823796
    8. Data suggest that G-patch domain of RBM5 is indispensable for its ability to interact with DHX15; RBM5 stimulates helicase activity of DHX15 in a G-patch domain-dependent manner. PMID: 22569250

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  • 亞細(xì)胞定位：
    Nucleus. Nucleus, nucleolus.
  • 蛋白家族：
    DEAD box helicase family, DEAH subfamily, DDX15/PRP43 sub-subfamily
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2738

    OMIM: 603403

    KEGG: hsa:1665

    STRING: 9606.ENSP00000336741

    UniGene: Hs.696074