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DNER Antibody

  • 中文名稱：
    DNER兔多克隆抗體
  • 貨號：
    CSB-PA818784NA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunofluorescence staining of U87 cells with CSB-PA818784NA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DNER Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DNER
  • 別名：
    bet antibody; Brain EGF repeat-containing transmembrane protein antibody; Bret antibody; Delta and Notch-like epidermal growth factor-related receptor antibody; Delta notch like EGF repeat containing transmembrane antibody; Delta/notch like EGF repeat containing antibody; Delta/notch-like EGF-related receptor antibody; Dner antibody; DNER_HUMAN antibody; PRO299 antibody; Transmembrane protein Bet antibody; UNQ26 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Peptide sequence from Human Delta and Notch-like epidermal growth factor-related receptor protein (150-168AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，DNER Antibody (CSB-PA818784NA01HU)，的標(biāo)記方式是Non-conjugated。對于DNER Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA818784NB01HU DNER Antibody, HRP conjugated ELISA
    FITC CSB-PA818784NC01HU DNER Antibody, FITC conjugated
    Biotin CSB-PA818784ND01HU DNER Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.
  • 基因功能參考文獻(xiàn)：
    1. quantum dot-based immunofluorescent imaging and quantitative analytical system (QD-IIQAS) is an easy and accurate method for assessing DNER and the DNER expression was an independent prognostic factor in prostate cancer. PMID: 29843212
    2. Collectively, our study identified an unexpected transcriptional repression function of the BET bromodomain and a novel mechanism for TAZ upregulation. PMID: 27717711
    3. our findings show that targeting BET proteins for degradation represents an effective therapeutic strategy for Triple-negative breast cancers (TNBC)treatment PMID: 28209615
    4. is not a Notch ligand PMID: 27622512
    5. we review and discuss the structural biology of BET family BDs and their applications in major diseases. PMID: 27240990
    6. DNER rs1861612 C to T change and variant T genotype may contribute to T2DM in a Chinese Han population PMID: 25300688
    7. These studies implicate DNER as a susceptibility gene for T2DM in American Indians. PMID: 24101674
    8. Our data suggest that clathrin-independent endocytosis is critical for the polarized targeting of somatodendritic proteins(DNER). PMID: 20367751
    9. The inhibition of DNER protein resulted in an increase in adipocyte maturation, partly via a reduction of cell proliferation through elevation of CCAAT-Enhancer-Binding Protein-delta expression. PMID: 20070733
    10. expression in developing and mature central nervous system PMID: 11950833

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed in brain, spinal cord and adrenal gland.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24456

    OMIM: 607299

    KEGG: hsa:92737

    STRING: 9606.ENSP00000345229

    UniGene: Hs.234074