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DOCK6 Antibody

  • 中文名稱：
    DOCK6兔多克隆抗體
  • 貨號(hào)：
    CSB-PA846633LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA846633LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DOCK6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DOCK6
  • 別名：
    Dedicator of cytokinesis protein 6 antibody; Dock6 antibody; DOCK6_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Dedicator of cytokinesis protein 6 protein (499-616AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，DOCK6 Antibody (CSB-PA846633LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于DOCK6 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA846633LB01HU DOCK6 Antibody, HRP conjugated ELISA
    FITC CSB-PA846633LC01HU DOCK6 Antibody, FITC conjugated
    Biotin CSB-PA846633LD01HU DOCK6 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth.
  • 基因功能參考文獻(xiàn)：
    1. acute knockdown of the Adams-Oliver syndrome (AOS) gene DOCK6, coding for a RAC1/CDC42 guanine nucleotide exchange factor, results in strikingly different phenotypes to those generated by genomic DOCK6 disruption. PMID: 27693507
    2. this study demonstrates that miR-142-3p is a key regulator of the TGFbeta-mediated contractile phenotype of VSMCs that acts through inhibiting cell migration through targeting DOCK6. PMID: 25832008
    3. DOCK6 mutations are responsible for a distinct autosomal-recessive variant of Adams-Oliver syndrome associated with brain and eye anomalies PMID: 25824905
    4. A homozygous truncating mutation in dedicator of cytokinesis 6 gene (DOCK6) which encodes an atypical guanidine exchange factor (GEF) known to activate two members of the Rho GTPase family: Cdc42 and Rac1, was identified. PMID: 21820096
  • 相關(guān)疾?。?/div>
    Adams-Oliver syndrome 2 (AOS2)
  • 亞細(xì)胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly located near the cell surface.
  • 蛋白家族：
    DOCK family
  • 組織特異性：
    Widely expressed. Expressed at low level in spleen, cerebellum, hippocampus and in substantia nigra.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 19189

    OMIM: 614194

    KEGG: hsa:57572

    STRING: 9606.ENSP00000294618

    UniGene: Hs.591002