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  4. DPY30 Antibody, FITC conjugated

DPY30 Antibody, FITC conjugated

  • 中文名稱：
    DPY30兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA861193LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DPY30 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DPY30
  • 別名：
    Dpy-30-like protein antibody; Dpy-30L antibody; DPY30 antibody; DPY30_HUMAN antibody; HDPY-30 antibody; Protein dpy-30 homolog antibody; Saf19 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Protein dpy-30 homolog protein (1-99AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.
  • 基因功能參考文獻(xiàn)：
    1. Dpy30 role in cellular reprogramming and its interactions with Set1 complex PMID: 26691508
    2. results indicate that DPY30 has critical roles in the proliferation, migration, and invasion of gastric cancer cells, and suggest DPY30 might be a therapeutic target in gastric cancer PMID: 26147337
    3. Based on our structural data and cross-linking results, we suggest that Dpy30 may regulate H3K4 methylation according to its copy number in COMPASS PMID: 25542209
    4. these results form the basis for understanding how WRAD(DRY-30) differentially regulates SET1 family complexes in vivo. PMID: 25561738
    5. The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells. PMID: 25139354
    6. A deletion mutation and reduced DPY30 expression in a Spastic Paraplegia type 4 Japanese family. PMID: 24690193
    7. DPY30 regulates pathways in cellular senescence through ID protein expression. PMID: 23872946
    8. determination of the minimum motif of Ash2L that is required for DPY30 interaction; a structural model for the Ash2L-DPY30 interaction PMID: 22231628
    9. First report of SPG4 associated with partial deletions of both the SPAST and DPY30 genes. The partial heterozygous deletion of DPY30 could modify the phenotypic expression of SPG4 patients with this pedigree. PMID: 20857310
    10. The DPY-30 C-terminal domain structure, harboring the conserved DPY-30 motif, is composed of two alpha-helices linked by a sharp loop and forms a typical X-type four-helix bundle required for dimer formation. PMID: 19481096
    11. hDPY-30 (dpy-30-like protein) binds ASH2L directly. The evolutionarily conserved hDPY-30, ASH2L, RBBP5 and WDR5 likely constitute a subcomplex that is shared by all human Set1-like HMT complexes. PMID: 17500065

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  • 亞細(xì)胞定位：
    Nucleus. Golgi apparatus, trans-Golgi network.
  • 蛋白家族：
    Dpy-30 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24590

    OMIM: 612032

    KEGG: hsa:84661

    STRING: 9606.ENSP00000295066

    UniGene: Hs.531788