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DSTN Antibody

  • 中文名稱：
    DSTN兔多克隆抗體
  • 貨號(hào)：
    CSB-PA007211GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    DSTN
  • 別名：
    2610043P17Rik antibody; ACTDP antibody; Actin depolymerizing factor antibody; Actin-depolymerizing factor antibody; ADF antibody; AU042046 antibody; bA462D18.2 antibody; corn1 antibody; DEST_HUMAN antibody; Destrin (actin depolymerizing factor) antibody; Destrin antibody; DSN antibody; Dstn antibody; Epididymis luminal protein 32 antibody; HEL32 antibody; Sid 23 antibody; sid23p antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human DSTN
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.
  • 基因功能參考文獻(xiàn)：
    1. analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover PMID: 26996939
    2. Destrin is upregulated in nerve-invasive pancreatic cancer cells and its expression might be related to perineural invasiveness PMID: 22898637
    3. The ADF/cofilin1-dependent severing of actin filaments exposes and promotes the activation of SPCA1, which pumps Ca(2+) into the lumen of the TGN for the sorting of the class of secretory cargo that binds Ca(2+). PMID: 21571222
    4. Changes in the expression of cytoskeletal regulatory proteins such as LIMK and cofilin may play a role in weakening thoracic aortic medial tissue, as a precondition to thoracic aortic dissection. PMID: 20873970
    5. The results of this study suggested that temporally regulated ADF/cofilin activities function in postsynaptic modifications of receptor number and spine size during synaptic plasticity. PMID: 20835250
    6. differences in actin binding by human ADF and cofilin PMID: 11812157
    7. Important sequence differences between actin-depolymerizing factor/cofilin were correlated with unique structural determinants in the F-actin-binding site to account for differences in biochemical activities of the two proteins. PMID: 14627701
    8. downregulated following UV exposure in epidermis PMID: 15816841
    9. In the absence of any crystal structures of ADF or cofilin in complex with actin, these studies provide further information about the binding sites on F-actin for these important actin regulatory proteins. PMID: 17196218
    10. destrin is a significant regulator of various processes important for invasive phenotype of human colon cancer Isreco1 cells whereas cofilin-1 may be involved in only a subset of them PMID: 17583572

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  • 蛋白家族：
    Actin-binding proteins ADF family
  • 組織特異性：
    Widely distributed in various tissues.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 15750

    OMIM: 609114

    KEGG: hsa:11034

    STRING: 9606.ENSP00000246069

    UniGene: Hs.304192