DTNB Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

O60941
基因名：

DTNB
別名：

Beta dystrobrevin antibody; Beta-dystrobrevin antibody; DTN B antibody; DTN-B antibody; Dtnb antibody; DTNB_HUMAN antibody; Dystrobrevin beta antibody; MGC17163 antibody; MGC57126 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human DTNB
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids. May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation. May be required for proper maturation and function of a subset of inhibitory synapses.
基因功能參考文獻：
1. Data provide new insights into the role of beta-dystrobrevin in the molecular mechanisms underlying neuronal differentiation that could be relevant in the establishment of the cognitive impairment in Duchene muscular dystrophy. PMID: 27223470
2. beta-dystrobrevin interacts with the HMG20 proteins iBRAF and BRAF35 PMID: 20530487
3. results suggest that dysbindin assembled into BLOC-1 is not a physiological binding partner of the dystrobrevins, likely due to engagement of its dystrobrevin-binding region in interactions with other subunits PMID: 16448387
亞細胞定位：

Cytoplasm. Cell junction, synapse, postsynaptic density. Cell projection, dendrite. Basal cell membrane. Cell junction, synapse, postsynapse. Nucleus.
蛋白家族：

Dystrophin family, Dystrobrevin subfamily
組織特異性：

Highly expressed in brain, kidney and pancreas.
數(shù)據(jù)庫鏈接：

HGNC: 3058

OMIM: 602415

KEGG: hsa:1838

STRING: 9606.ENSP00000384084

UniGene: Hs.307720