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EIF3C Antibody

  • 中文名稱：
    EIF3C兔多克隆抗體
  • 貨號：
    CSB-PA857867LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: MCF-7 whole cell lysate, Hela whole cell lysate, A375 whole cell lysate
      All lanes: EIF3C antibody at 3.4μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 106, 105 kDa
      Observed band size: 106 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA857867LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA857867LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) EIF3C Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    EIF3C
  • 別名：
    Cell migration inducing protein 17 antibody; eIF 3c antibody; eIF3 p110 antibody; eIF3-p110 antibody; eIF3c antibody; EIF3C_HUMAN antibody; EIF3CL antibody; EIF3S8 antibody; EIF3S8 protein antibody; Eukaryotic translation initiation factor 3 subunit 8 (110kD) antibody; Eukaryotic translation initiation factor 3 subunit 8 110kDa antibody; Eukaryotic translation initiation factor 3 subunit 8 antibody; Eukaryotic translation initiation factor 3 subunit C antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Eukaryotic translation initiation factor 3 subunit C protein (201-500AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，EIF3C Antibody (CSB-PA857867LA01HU)，的標(biāo)記方式是Non-conjugated。對于EIF3C Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA857867LB01HU EIF3C Antibody, HRP conjugated ELISA
    FITC CSB-PA857867LC01HU EIF3C Antibody, FITC conjugated
    Biotin CSB-PA857867LD01HU EIF3C Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:2000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
  • 基因功能參考文獻(xiàn)：
    1. In EIF3C-positive tumors, 32 out of 42 showed significantly higher frequencies of high grade group by immunoreactivity. PMID: 28854163
    2. High eIF3c expression is positively associated with KRAS. PMID: 28231410
    3. These findings suggest that eIF3c is overexpressed in human gliomas and essential for their proliferation and survival. PMID: 25823503
    4. eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome. PMID: 24092755
    5. Collectively, eIF3c deletion effectively reduced the survival of colon cancer cells and could be used as a therapeutic tool for colon cancer therapy. PMID: 23733421
    6. These results indicate that the interaction between Hsp90 and eIF3c may play an important role in hepatitis C virus internal ribosome entry site-mediated translation. PMID: 22016036

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  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    EIF-3 subunit C family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3279

    OMIM: 603916

    KEGG: hsa:8663

    STRING: 9606.ENSP00000332604

    UniGene: Hs.567374