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  4. EME1 Antibody

EME1 Antibody

  • 中文名稱：
    EME1兔多克隆抗體
  • 貨號：
    CSB-PA007634GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    EME1
  • 別名：
    6820428D13 antibody; Crossover junction endonuclease EME1 antibody; EC 3.1.22.- antibody; EME1 antibody; Eme1 essential meiotic endonuclease 1 homolog 1 (S. pombe) antibody; EME1; S. pombe; homolog of; 1 antibody; EME1_HUMAN antibody; essential meiotic endonuclease 1 homolog 1 (S pombe) antibody; Essential Meiotic Endonuclease 1 Homolog 1 antibody; essential meiotic endonuclease 1 homolog 2 antibody; Essential meiotic endonuclease 1; S. pombe; homolog of; 1 antibody; FLJ31364 antibody; hMMS4 antibody; homolog of yeast EME1 endonuclease antibody; MGC106543 antibody; MMS4 antibody; MMS4 homolog antibody; MMS4L antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human EME1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
  • 基因功能參考文獻(xiàn)：
    1. The data suggest that subnuclear relocalization is relevant for the function of Mus81-Mms4 complex in response to DNA damage and, probably, of the endonucleases that colocalize with it. PMID: 28813668
    2. EME-1 deficiency affects cell cycle progression and promotes DNA rereplication. PMID: 16456034
    3. Low Eme1 levels were more sensitive to the drug than tumors with high levels. PMID: 19267403
  • 亞細(xì)胞定位：
    Nucleus, nucleolus. Note=Recruited to regions of DNA damage in S-phase cells.
  • 蛋白家族：
    EME1/MMS4 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24965

    OMIM: 610885

    KEGG: hsa:146956

    STRING: 9606.ENSP00000376952

    UniGene: Hs.514330