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FAM111A Antibody, FITC conjugated

  • 中文名稱：
    FAM111A兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA853484LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) FAM111A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    FAM111A
  • 別名：
    FAM111A antibody; KIAA1895Protein FAM111A antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Protein FAM111A protein (26-179AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Single-stranded DNA-binding serine protease that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde. Protects replication fork from stalling by removing DPCs, such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesion, or poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors. Required for PCNA loading on replication sites. Promotes S-phase entry and DNA synthesis.; (Microbial infection) May directly function at replication forks, explaining why Simian virus 40 (SV40) interacts with FAM111A to overcome host range restriction.
  • 基因功能參考文獻(xiàn)：
    1. Together, these data suggest that FAM111A may also be important in the development and function of male genitalia. 394 PMID: 24635597
    2. study would provide evidence that FAM111A is a key molecule for normal bone development, height gain, and parathyroid hormone development and/or regulation PMID: 23996431
    3. FAM111A is a replication factor required for PCNA loading. PMID: 24561620
    4. FAM111A appears to be crucial to a pathway that governs parathyroid hormone production, calcium homeostasis, and skeletal development and growth. PMID: 23684011
    5. FAM111A functions as a host range restriction factor that is specifically targeted by SV40 large T antigen PMID: 23093934

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  • 相關(guān)疾病：
    Kenny-Caffey syndrome 2 (KCS2); Gracile bone dysplasia (GCLEB)
  • 亞細(xì)胞定位：
    Nucleus. Chromosome. Cytoplasm.
  • 蛋白家族：
    FAM111 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 24725

    OMIM: 127000

    KEGG: hsa:63901

    UniGene: Hs.150651