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FANK1 Antibody

  • 中文名稱：
    FANK1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA819458HA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunofluorescence staining of MCF-7 cells with CSB-PA819458HA01HU at 1:333, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA819458HA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) FANK1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    1700007B22Rik antibody; AI850911 antibody; Fank1 antibody; FANK1_HUMAN antibody; Fibronectin type 3 and ankyrin repeat domains 1 antibody; Fibronectin type 3 and ankyrin repeat domains protein 1 antibody; Fibronectin type III and ankyrin repeat domains 1 antibody; HSD13 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Fibronectin type 3 and ankyrin repeat domains protein 1 protein (1-345AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，F(xiàn)ANK1 Antibody (CSB-PA819458HA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于FANK1 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA819458HB01HU FANK1 Antibody, HRP conjugated ELISA
    FITC CSB-PA819458HC01HU FANK1 Antibody, FITC conjugated
    Biotin CSB-PA819458HD01HU FANK1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:500
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis.
  • 基因功能參考文獻(xiàn)：
    1. RYBP activates FANK1-mediated activator protein 1 (AP-1) signaling pathway which contributes to tumor cell apoptosis. PMID: 27060496
    2. we find evidence for many novel candidates, the strongest of which is FANK1, an imprinted gene that suppresses apoptosis, is expressed during meiosis in males. PMID: 25144706
    3. the TNfnIII 1-5 repeats play an important role in PCO pathology. PMID: 25515583
    4. found that Jab1 (Jun activation domain-binding protein 1), a co-activator of AP-1, specifically interacted with Fank1 PMID: 20978819
    5. FANK1 may have a role in regulating gene expression in the transition from the meiotic phase to the haploid phase during spermatogenesis PMID: 17604233

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  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium.
  • 組織特異性：
    Mostly restricted to testis.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 23527

    OMIM: 611640

    KEGG: hsa:92565

    STRING: 9606.ENSP00000357682

    UniGene: Hs.352591