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  4. FBXO22 Antibody

FBXO22 Antibody

  • 中文名稱：
    FBXO22兔多克隆抗體
  • 貨號：
    CSB-PA854115ESR2HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: FBXO22 antibody at 2.42 μg/ml
      Lane 1: Mouse heart tissue
      Lane 2: Mouse liver tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 45, 5, 31 kDa
      Observed band size: 45 kDa
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA854115ESR2HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) FBXO22 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    FBXO22
  • 別名：
    0610033L19Rik antibody; 1600016C16Rik antibody; F box only protein 22 antibody; F box protein 22 antibody; F box protein FBX22p44 antibody; F-box only protein 22 antibody; F-box protein FBX22p44 antibody; FBX22 antibody; FBX22_HUMAN antibody; FBXO 22 antibody; FBXO22 antibody; FIST domain containing 1 antibody; FISTC1 antibody; FLJ13986 antibody; MGC124731 antibody; MGC31799 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human F-box only protein 22 protein (104-403AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.
  • 基因功能參考文獻：
    1. Data show that FBXO22 mediated the polyubiquitination and degradation of CD147 by interacting with CD147 intracellular domain (CD147-ICD). PMID: 28117675
    2. Authors demonstrate that F-box only protein 22 (FBXO22) interacts with and thereby destabilizes KLF4 via polyubiquitination. As a result, FBXO22 could promote HCC cells proliferation. PMID: 26087183
    3. Results indicate that SCF(Fbxo22)-KDM4A is an E3 ubiquitin ligase that targets methylated p53 and regulates key senescent processes. PMID: 26868148
    4. FBXO22 protein is required for optimal synthesis of NMDA receptor coagonist D-serine by interacting with serine racemase, activating it, and preventing its targeting to membranes. PMID: 25336657
    5. we determined that the phage-encoded GogB effector protein in Salmonella targets the host SCF E3 type ubiquitin ligase through an interaction with Skp1 and the human F-box only 22 (FBXO22) protein PMID: 22761574
    6. FBXO22 is a key regulator of histone methylation marks, namely, H3K9 and H3K36 methylation, through the regulation of KDM4A protein levels. PMID: 21768309

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  • 亞細胞定位：
    Cytoplasm, myofibril, sarcomere, Z line.
  • 組織特異性：
    Predominantly expressed in liver, also enriched in cardiac muscle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13593

    OMIM: 609096

    KEGG: hsa:26263

    STRING: 9606.ENSP00000307833

    UniGene: Hs.591115