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FBXW4 Antibody

  • 中文名稱：
    FBXW4兔多克隆抗體
  • 貨號：
    CSB-PA008525ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA008525ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) FBXW4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    FBXW4
  • 別名：
    FBXW4 antibody; FBW4 antibody; SHFM3 antibody; F-box/WD repeat-containing protein 4 antibody; Dactylin antibody; F-box and WD-40 domain-containing protein 4 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human F-box/WD repeat-containing protein 4 protein (143-412AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.
  • 基因功能參考文獻：
    1. biochemical characterization of the novel F-box and WD40 containing protein, FBXW4 PMID: 23658844
    2. a complex rearrangement associated with a approximately 0.5 Mb tandem duplication ion containing a disrupted extra copy of the DACTYLIN gene and the entire LBX1 and beta-TRCP genes. PMID: 12913067
    3. results indicate that genomic rearrangement of SHFM3 is rare among non-syndromic SHFM patients and emphasize the importance of screening for genomic rearrangements even in sporadic cases of SHFM PMID: 16235095
    4. Genomic rearrangements involving the SHFM3 locus at chromosome 10q24 is associated with syndromic and non-syndromic split-hand/foot malformation PMID: 16761290
  • 相關(guān)疾?。?/div>
    Split-hand/foot malformation 3 (SHFM3)
  • 組織特異性：
    Expressed in brain, kidney, lung and liver.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10847

    OMIM: 246560

    KEGG: hsa:6468

    STRING: 9606.ENSP00000373698

    UniGene: Hs.500822