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  4. FCGRT Antibody, FITC conjugated

FCGRT Antibody, FITC conjugated

Rare Species
  • 中文名稱：
    FCGRT兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA851443LC01MOV
  • 規(guī)格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Macaca fascicularis FCGRT Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    FCGRT antibody; FCRNIgG receptor FcRn large subunit p51 antibody; FcRn antibody; IgG Fc fragment receptor transporter alpha chain antibody; Neonatal Fc receptor antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Macaca fascicularis
  • 免疫原：
    Recombinant Macaca fascicularis IgG receptor FcRn large subunit p51 protein (24-297AA)
  • 免疫原種屬：
    Macaca fascicularis
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB.
  • 基因功能參考文獻：
    1. None of the non-synonymous variants of FCGRT or B2M found changes in the amino acid residues known to be important for FcRn function, suggesting that substantial inter-animal variability of FcRn is not expected for the cynomolgus macaques analyzed PMID: 24806819
    2. Characterization and screening of IgG binding to the neonatal Fc receptor. PMID: 24802048
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Endosome membrane.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 數(shù)據(jù)庫鏈接：

    KEGG: mcf:102128913

    UniGene: Mfa.8387