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FCHSD2 Antibody

  • 中文名稱：
    FCHSD2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA008549LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: FCHSD2 antibody at 12µg/ml
      Lane 1: U251 whole cell lysate
      Lane 2: A549 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 85, 78, 59 kDa
      Observed band size: 85 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA008549LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA008549LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) FCHSD2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    FCHSD2
  • 別名：
    FCHSD2 antibody; KIAA0769 antibody; SH3MD3F-BAR and double SH3 domains protein 2 antibody; Carom antibody; Protein nervous wreck 1 antibody; NWK1 antibody; SH3 multiple domains protein 3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human F-BAR and double SH3 domains protein 2 protein (1-290AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，F(xiàn)CHSD2 Antibody (CSB-PA008549LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于FCHSD2 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA008549LB01HU FCHSD2 Antibody, HRP conjugated ELISA
    FITC CSB-PA008549LC01HU FCHSD2 Antibody, FITC conjugated
    Biotin CSB-PA008549LD01HU FCHSD2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor. Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling. Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits. Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes.
  • 基因功能參考文獻(xiàn)：
    1. Loss of FCHSD2 activity in nonsmall cell lung cancer (NSCLC) cells leads to increased cell-surface expression and altered signaling downstream of EGFR, resulting in enhanced cell proliferation and migration. PMID: 30249660
    2. Established 3 models of Carom-receptor complexes and their intracellular trafficking based on protein interaction and subcellular localization. Carom may mediate receptor endocytosis and transport endocytic receptors to the cytoplasm for receptor signaling and lysosome/proteasome degradation. Review. PMID: 28199211
    3. A novel SNP-systemic lupus erythematosus association was identified between FCHSD2 and P2RY2, peaking at rs11235667 on a 33-kb haplotype upstream of ATG16L2. PMID: 26663301
    4. our study, for the first time, demonstrates FCHSD2 as a predictor of outcome for Acute myeloid leukemia patients PMID: 22902056
  • 亞細(xì)胞定位：
    Cytoplasm. Cell junction. Membrane, clathrin-coated pit. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, stereocilium.
  • 組織特異性：
    Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 29114

    OMIM: 617556

    KEGG: hsa:9873

    STRING: 9606.ENSP00000386722

    UniGene: Hs.744959