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  4. FCRL4 Antibody, Biotin conjugated

FCRL4 Antibody, Biotin conjugated

  • 中文名稱：
    FCRL4兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA836277LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) FCRL4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CD307d antibody; Fc receptor homolog 4 antibody; Fc receptor like 4 antibody; Fc receptor like protein 4 antibody; Fc receptor-like protein 4 antibody; FcR like protein 4 antibody; FcR-like protein 4 antibody; FcRH4 antibody; FcRL4 antibody; FCRL4_HUMAN antibody; hIFGP2 antibody; IFGP family protein 2 antibody; IGFP2 antibody; Immune receptor translocation associated protein 1 antibody; Immune receptor translocation-associated protein 1 antibody; Immunoglobulin superfamily receptor translocation associated 1 antibody; Immunoglobulin superfamily receptor translocation associated gene 1 antibody; IRTA1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Fc receptor-like protein 4 protein (20-387AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.
  • 基因功能參考文獻：
    1. We conclude that these activated B cells are a component of the local autoimmune response, and through their RANKL expression, can contribute to joint destruction. Furthermore, their expression of FcRL4 and their enrichment in the IgA isotype points towards a potential role for these cells in the link between mucosal and joint inflammation. PMID: 28343748
    2. intraepithelial FcRL4(+) B-cells are present in the salivary glands of pSS patients. These cells are likely involved in the epithelial changes seen in pSS. Their enrichment in parotid glands may explain why MALT lymphomas in pSS patients preferentially develop at this specific location. PMID: 28390747
    3. Commercially available IRTA1 antibody can immunohistochemically distinguish MALT lymphoma from other low-grade B-cell lymphomas. PMID: 27666766
    4. Significantly increased FCRL4 mRNA only in Graves disease patients but not in Hashimoto patients compared to normal controls. PMID: 25738996
    5. The observed significant gene-environment interaction suggests that drinking and cooking oil use with FCRL4 gene polymorphism has a significant interaction. PMID: 25012527
    6. we provide evidence for involvement of HCK and FGR in FCRL4-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 molecule. PMID: 25972488
    7. IRTA1 and T-bet are positive markers for the diagnosis of nodal marginal zone lymphoma PMID: 23855758
    8. Data indicate that signaling by HIV-1 gp120 through integrin alpha4beta7 resulted in increased expression of the immunosuppressive cytokine TGF-beta1 and FcRL4. PMID: 24162774
    9. The cytological features, growth pattern and IRTA1 positivity in nodal marginal zone lymphomas suggest they may derive from IRTA1(+) perifollicular B cells or monocytoid B cells detectable in reactive lymph nodes. PMID: 22716304
    10. The FCRL4 polymorphisms may play an important role in the susceptibility and severity of ankylosing spondylitis in the Chinese Han population. PMID: 22777505
    11. In cellular binding assays, as a bona fide receptor FcRL4 binds efficiently to immunoglobulin (Ig)A. PMID: 22491254
    12. Data suggest that expression of FcRL4 in B-cells results in inhibition of BCR signaling at point of Syk phosphorylation by mechanism that involves phosphorylation of FcRL4 and its association with SHP-1/SHP-2. PMID: 21908428
    13. role of IRTA1 in the immune function of B cells within epithelia PMID: 12881317
    14. Monocytoid B cells differ in their antigen profile (presence of IRTA1) from splenic and nodal marginal zone B cells. PMID: 16079106
    15. Cell surface expression of this immunoregulatory molecule is restricted to a subpopulation of memory B cells. PMID: 16157685
    16. Down-regulation of FCRL4 is associated with acute lymphoblastic leukemia. PMID: 18802695
    17. FCRL4 is located on atypical memory B cells population significantly expanded in Plasmodium falciparum-exposed Malian adults and children PMID: 19592645

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  • 相關(guān)疾?。?/div>
    A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2).
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18507

    OMIM: 605876

    KEGG: hsa:83417

    STRING: 9606.ENSP00000271532

    UniGene: Hs.120260