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  4. FPR3 Antibody
  • 中文名稱：
    FPR3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA008856LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA008856LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA008856LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA008856LA01HU at dilution of 1:100 and Cy3-congugated Goat Anti-Rabbit IgG
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) FPR3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    FPR3; FPRH1; FPRL2; N-formyl peptide receptor 3; FMLP-related receptor II; FMLP-R-II; Formyl peptide receptor-like 2
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human N-formyl peptide receptor 3 protein (307-353AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，F(xiàn)PR3 Antibody (CSB-PA008856LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于FPR3 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA008856LB01HU FPR3 Antibody, HRP conjugated ELISA
    FITC CSB-PA008856LC01HU FPR3 Antibody, FITC conjugated
    Biotin CSB-PA008856LD01HU FPR3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

平均分:
5.0分 - 1 個(gè)評(píng)價(jià)

實(shí)驗(yàn)應(yīng)用：IHC

樣品信息：乳腺癌 人

稀釋比：1：150

產(chǎn)品評(píng)價(jià)： 我使用CSB-PA008856LA01HU抗體，進(jìn)行乳腺癌患者免疫組化檢測(cè)，按照1：150稀釋度，能夠達(dá)到較好的結(jié)果。推薦使用。

By 唐老師

靶點(diǎn)詳情

  • 功能：
    Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Acts as a receptor for humanin.
  • 基因功能參考文獻(xiàn)：
    1. The demonstrated proper folding and functionality of the cell-free produced human FPR3 opens a new avenue for the fast and efficient generation of human FPRs (and even other GPCRs) for structural and functional analysis. PMID: 23746112
    2. transcriptional variations of FPR3 occur by an alternative promoter during primate evolution. PMID: 21717223
    3. F2L peptide, derived from the processing of nanomolar concentrations of heme-binding protein (HEBP)1, is active on FPR3 and able to induce recruitment of FPR3-expressing monocytes, macrophages, and mouse neutrophils PMID: 21709160
    4. Results show that uPAR expression regulates the adhesive and migratory ability of CXCR4-expressing cells through a mechanism involving fMLP receptors and alpha-v integrins. PMID: 20972812
    5. Human dendritic cells express functional FPRL2 throughout maturation. FPRL2 & its endogenous ligand may be involved in regulating DC trafficking during Ag uptake & processing s well as the T-cell-stimulating phase of the immune responses. PMID: 12223529
    6. Activation of FPRL2 inhibits lipopolysaccharide-induced dendritic cell maturation. PMID: 16002663
    7. However, F2L inhibits formyl peptide receptor (FPR) and FPRL1 activities, resulting in the inhibition of intracellular calcium increases, and superoxide generation induced by N-formyl-Met-Leu-Phe, MMK-1, or Trp-Lys-Tyr-Met-Val-d-Met in neutrophils. PMID: 17577578
    8. FPRL2 is expressed and functional in macrophages differentiated from monocytes in vitro in different conditions PMID: 19342677
    9. Human monocytes express FPR1, FPR2, and FPR3; human neutrophils express FPR1 and FPR2, but not FPR3. PMID: 19843937

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Detected in various tissues with highest expression in lung.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 3828

    OMIM: 136539

    KEGG: hsa:2359

    STRING: 9606.ENSP00000341821

    UniGene: Hs.445466