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GIT2 Antibody

  • 中文名稱：
    GIT2兔多克隆抗體
  • 貨號：
    CSB-PA613489LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA613489LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA613489LA01HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) GIT2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    ARF GAP GIT2 antibody; ARF GTPase activating protein GIT2 antibody; ARF GTPase-activating protein GIT2 antibody; CAT 2 antibody; CAT-2 antibody; CAT2 antibody; Cool associated tyrosine phosphorylated protein 2 antibody; Cool interacting tyrosine phosphorylated protein 2 antibody; Cool-interacting tyrosine-phosphorylated protein 2 antibody; DKFZp686G01261 antibody; G protein coupled receptor kinase interacting ArfGAP 2 antibody; G protein coupled receptor kinase interactor 2 antibody; G protein-coupled receptor kinase-interactor 2 antibody; GIT 2 antibody; GIT2 antibody; GIT2_HUMAN antibody; GRK interacting protein 2 antibody; GRK-interacting protein 2 antibody; KIAA0148 antibody; MGC760 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human ARF GTPase-activating protein GIT2 protein (1-603AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，GIT2 Antibody (CSB-PA613489LA01HU)，的標記方式是Non-conjugated。對于GIT2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA613489LB01HU GIT2 Antibody, HRP conjugated ELISA
    FITC CSB-PA613489LC01HU GIT2 Antibody, FITC conjugated
    Biotin CSB-PA613489LD01HU GIT2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    GTPase-activating protein for ADP ribosylation factor family members, including ARF1.
  • 基因功能參考文獻：
    1. our work identifies DOCK5 as a key regulator of epithelial invasion and metastasis, and demonstrates that suppression of DOCK5 by GIT2 represents a previously unappreciated mechanism for coordination of Rho and Rac GTPases. PMID: 27669437
    2. Short-term EGF stimulation if of lung tumor cells can increase the interaction between RUSC2 and GIT2, prolonged stimulation leads to a decrease of their interaction through activating Rab35. PMID: 27238570
    3. GIT2 plays an important role in MRE11/ATM/H2AX-mediated DNA damage responses. PMID: 25605334
    4. ADMA and L-arginine are substrates of human CAT2A, CAT2B, OCT2 and MATE1. Transport kinetics of CAT2A, CAT2B, and OCT2 indicate a low affinity, high capacity transport, which may be relevant for renal and hepatic elimination of ADMA or L-arginine PMID: 23864433
    5. Zeb1 is regulated by the Arf GTPase-activating protein (GAP) Git2. PMID: 23591815
    6. GIT2 protein is tightly associated with PIX family Rac1/Cdc42 guanine nucleotide exchange factors as a multimeric nexus capable of linking together important signaling molecules. PMID: 15212761
    7. The expression level of lymphocyte GRK might show the severity of CHF, and ACEI treatment could reduce the level of GRK in CHF patients. PMID: 16501306
    8. GTI proteins regulate cytoskeletal dynamics by feedback inhibition of Rac1, they participate in receptor internalization by regulating membrane trafficking between PMID: 16598076
    9. These results suggest that inactivation of GIT2 function is a required step for induction of cell motility and that GIT2 may be a target of oncogenic signaling pathways that regulate cell migration. PMID: 16628223
    10. Git2-short, weakly interacting with paxillin, functions in the regulation of Golgi organization, actin cytoskeletal organization, and subcellular localization of paxillin, important in integrin-mediated cell adhesion and intracellular signaling. PMID: 11251077

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  • 數(shù)據(jù)庫鏈接：

    HGNC: 4273

    OMIM: 608564

    KEGG: hsa:9815

    STRING: 9606.ENSP00000347464

    UniGene: Hs.434996