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  4. GNRH2 Antibody, FITC conjugated

GNRH2 Antibody, FITC conjugated

  • 中文名稱：
    GNRH2兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA009636LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) GNRH2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GNRH2
  • 別名：
    GnRH II antibody; GnRH-associated peptide 2 antibody; GnRH-associated peptide II antibody; gnrh2 antibody; GON2_HUMAN antibody; Gonadoliberin II antibody; Gonadotropin-releasing hormone 2 antibody; Gonadotropin-releasing hormone II antibody; LH-RH II antibody; Luliberin II antibody; Luteinizing hormone-releasing hormone II antibody; Progonadoliberin 2 antibody; Progonadoliberin II antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Progonadoliberin-2 protein (24-120AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
  • 基因功能參考文獻(xiàn)：
    1. GnRHII expression correlated significantly with poor prognosis in breast cancer patients. PMID: 23287110
    2. results suggest GnRH-II-induced laminin receptor precursor expression increases 67-kDa nonintegrin laminin receptor, which appears to interact with laminin in the extracellular matrix to promote MMP-2 expression and enhance ovarian cancer cell invasion PMID: 21193558
    3. concluded that GnRHII stimulates PI3K/Akt pathway, and the phosphorylation of glycogen synthase kinase3beta, thereby enhancing the beta-catenin-dependent up-regulation of MT1-MMP production which contributes to ovarian cancer metastasis PMID: 21239435
    4. These preliminary data suggest that local GnRH-II may participate in the regulation of ovarian tumor growth in post-menopausal women. PMID: 20018426
    5. a novel mechanism in stimulating basal human GnRH-II gene transcription mediated by cooperative actions of multiple regulatory elements within the untranslated first exon of the gene. PMID: 12663744
    6. GnRH-II has been identified, together with a 'putative' type II GnRH receptor, both in the central nervous system and in peripheral structures, such as tissues of the reproductive tract (both normal and tumoral). PMID: 14726258
    7. GnRH-II did not affect proliferation of normal B-cells alone, and did not alter the proliferative response to IL-2. PMID: 15578334
    8. Expression of GnRH2 protein and receptor (GnRHR2) is confirmed in both leiomyoma and patient-matched myometrium. PMID: 17296196
    9. these data demonstrate the differential roles of NF-kappaB p65 and RARalpha/RXRalpha, interacting with the same sequence in the promoter of the human GnRH II gene to influence gene expression in a cell-specific manner. PMID: 17451432
    10. GnRH II is widely expressed in prostate cancer and is an AR-regulated gene. PMID: 17914092
    11. p-CREB, C/EBPbeta, and CBP are recruited to the CRE of the GnRH-II promoter in a temporarily defined manner to enhance its transcription in JEG-3 and OVCAR-3 cells in response to cAMP PMID: 18599546
    12. These results provide evidence that EGF is an upstream regulator of the autocrine actions of GnRH-II on the invasive properties of ovarian cancer cells. PMID: 19608641

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    GnRH family
  • 組織特異性：
    Midbrain; expressed at significantly higher levels outside the brain (up to 30-fold), particularly in the kidney, bone marrow and prostate.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4420

    OMIM: 602352

    KEGG: hsa:2797

    STRING: 9606.ENSP00000245983

    UniGene: Hs.129715