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GORAB Antibody

  • 中文名稱(chēng)：
    GORAB兔多克隆抗體
  • 貨號(hào)：
    CSB-PA005600
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of AD293 cells using SCYL1BP1 Polyclonal Antibody.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    FLJ11752 antibody; GO antibody; Golgin RAB6 interacting antibody; GORAB antibody; GORAB_HUMAN antibody; hNTKL BP1 antibody; hNTKL-BP1 antibody; MGC51263 antibody; MGC70512 antibody; N terminal kinase like binding protein 1 antibody; N-terminal kinase-like-binding protein 1 antibody; NTKL binding protein 1 antibody; NTKL BP1 antibody; NTKL-binding protein 1 antibody; NTKL-BP1 antibody; NTKLBP 1 antibody; NTKLBP1 antibody; OTTHUMP00000033164 antibody; RAB6-interacting golgin antibody; RP11 545I10.1 antibody; SCY1 like 1 binding protein 1 antibody; SCY1-like 1-binding protein 1 antibody; SCYL1 binding protein 1 antibody; SCYL1 BP1 antibody; SCYL1-binding protein 1 antibody; SCYL1-BP1 antibody; SCYL1BP1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human SCYL1BP1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. Novel compound heterozygous nonsense mutations were identified in the GORAB gene of a geroderma osteodysplastica patient. PMID: 28807865
    2. in the present study a de novo deletion on 1q23.3-q24.2 combined with a GORAB missense mutation leads to a distinctive phenotype with features from Gerodermia osteodysplastica and also short stature, cutis laxa, frequent fractures, facial dysmorphism, cup-shaped ears and intellectual disability PMID: 27604556
    3. SCYL1- BP1 affects the cell cycle through increasing steady state levels of Cyclin F and RRM2 proteins, thus constituting a dual regulatory circuit PMID: 25980818
    4. SCYL1-BP1 plays a critical role in the regulation of EEA1, BMPR2 and BRCA2 expression. PMID: 25234469
    5. SCYL1BP1 can promote the degradation of MDM2 protein and further inhibit the G1/S transition of lung SCC lines. Reintroduction of SCYL1BP1 into lung SCC lines significantly inhibited cell proliferation, migration, invasion and tumor formation. PMID: 25227860
    6. Data suggest that SCYL1-BP1 is a novel regulator of the MDM2-p53 feedback loop and that it may be a potential tumor suppressor. PMID: 20849854
    7. The chemotaxis signal pathway induced by chemokines CKbeta8 and CKbeta8-1 is mediated via the Gi/Go protein, phospholipase C (PLC) and protein kinase C delta (PKC delta). PMID: 19951712
    8. study supplements the limited available data on SCYL1BP1 and further establishes deficiency of this recently described golgin as the only known cause of geroderma osteodysplastica PMID: 19681135
    9. assessment of interaction with hPirh2 PMID: 15781263
    10. Study demonstrates that gerodermia osteodysplastica is caused by loss-of-function mutations in SCYL1BP1, which is highly expressed in skin and osteoblasts. PMID: 18997784

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  • 相關(guān)疾?。?/div>
    Geroderma osteodysplasticum (GO)
  • 亞細(xì)胞定位：
    Cytoplasm. Golgi apparatus.
  • 蛋白家族：
    GORAB family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 25676

    OMIM: 231070

    KEGG: hsa:92344

    STRING: 9606.ENSP00000356737

    UniGene: Hs.183702